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C104450

Cycloheximide

Name: Cycloheximide
Brand: ALDRICH

98%

Synonym(s):

3-[2-(3,5-Dimethyl-2-oxocyclohexyl)-2-hydroxyethyl]glutarimide, Actidione, Naramycin A

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About This Item

Empirical Formula (Hill Notation):

C₁₅H₂₃NO₄

CAS Number:

66-81-9

Molecular Weight:

281.35

EC Number:

200-636-0

UNSPSC Code:

12352103

MDL number:

MFCD00082346

Beilstein/REAXYS Number:

88868

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Properties

assay

98%

SMILES string

[H][C@]1(C[C@@H](C)C[C@H](C)C1=O)[C@H](O)CC2CC(=O)NC(=O)C2

InChI

1S/C15H23NO4/c1-8-3-9(2)15(20)11(4-8)12(17)5-10-6-13(18)16-14(19)7-10/h8-12,17H,3-7H2,1-2H3,(H,16,18,19)/t8-,9-,11-,12+/m0/s1

InChI key

YPHMISFOHDHNIV-FSZOTQKASA-N

Description

Application

Inhibitor of protein synthesis.

Biochem/physiol Actions

Mode of Action: Translation inhibition in eukaryotes resulting in cell growth arrest and cell death. CHX is widely used for the selection of CHX-resistant strains of yeast and fungi, controlled inhibition of protein synthesis for detection of short-lived proteins and super-induction of protein expression, and apoptosis induction or facilitation of apoptosis induction by death receptors.

Activity Spectrum: Active against yeast and fungi like Candida, Aspergillus, Saccharomyces, Penicillium

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pictograms

GHS06,GHS08,GHS09

signalword

Danger

hcodes

H300,H341,H360D,H411

pcodes

P202 - P264 - P270 - P273 - P280 - P301 + P310

Hazard Classifications

Acute Tox. 2 Oral - Aquatic Chronic 2 - Muta. 2 - Repr. 1B

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

Regulatory Information

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The in vitro PIG-A gene mutation assay: mutagenicity testing via flow cytometry based on the glycosylphosphatidylinositol (GPI) status of TK6 cells.

Christopher T Krüger et al.

Archives of toxicology, 89(12), 2429-2443 (2014-11-25)

The X-linked PIG-A gene is involved in the biosynthesis of the cell surface anchor GPI, and its inactivation may serve as a new marker for mutagenicity. The in vivo PIG-A gene mutation assay is currently being validated by several groups.

Global Trade Item Number

SKU	GTIN
W293008-SAMPLE-K	04061838181572
W293008-10KG-K	04061838257475
W293008-5KG-K	04061838257499
W293008-1KG-K	04061838257482