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C106402

N-Cyclohexyl-N′-(2-morpholinoethyl)carbodiimide methyl-p-toluenesulfonate

Name: N-Cyclohexyl-N′-(2-morpholinoethyl)carbodiimide methyl-p-toluenesulfonate
Brand: ALDRICH

95%

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Synonym(s):

4-[2-[(Cyclohexylcarbonimidoyl)amino]ethyl]-4-methylmorpholinium p-toluenesulfonate, N-Cyclohexyl-N′-(β-[N-methylmorpholino]ethyl)carbodiimide p-toluenesulfonate salt, CMC, CMC metho-p-toluenesulfonate, Morpho CDI

Empirical Formula (Hill Notation):

C₁₄H₂₆N₃O · C₇H₇O₃S

CAS Number:

2491-17-0

Molecular Weight:

423.57

EC Number:

219-650-3

MDL number:

MFCD00011979

PubChem Substance ID:

329774842

NACRES:

NA.26

Quality Level

200

Assay

95%

form

crystals

mp

113-115 °C (lit.)

SMILES string

Cc1ccc(cc1)S([O-])(=O)=O.C[N+]2(CCOCC2)CCN=C=NC3CCCCC3

InChI

1S/C14H26N3O.C7H8O3S/c1-17(9-11-18-12-10-17)8-7-15-13-16-14-5-3-2-4-6-14;1-6-2-4-7(5-3-6)11(8,9)10/h14H,2-12H2,1H3;2-5H,1H3,(H,8,9,10)/q+1;/p-1

InChI key

GBCAVSYHPPARHX-UHFFFAOYSA-M

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Application

Employed in a facile sequencing technique for pseudouridylate residues in RNA.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Four newly located pseudouridylate residues in Escherichia coli 23S ribosomal RNA are all at the peptidyltransferase center: analysis by the application of a new sequencing technique.

A Bakin et al.

Biochemistry, 32(37), 9754-9762 (1993-09-21)

A new technique has been developed for the facile location of pseudouridylate (psi) residues in any RNA molecule. The method uses two known modification procedures which in combination uniquely identify U residues which have been converted into psi. The first

A recombinant antibody against Plasmodium vivax UIS4 for distinguishing replicating from dormant liver stages.

Carola Schafer et al.

Malaria journal, 17(1), 370-370 (2018-10-20)

Plasmodium vivax is the most geographically widespread of the human malaria parasites, causing 50,000 to 100,000 deaths annually. Plasmodium vivax parasites have the unique feature of forming dormant liver stages (hypnozoites) that can reactivate weeks or months after a parasite-infected

Identification of the mass-silent post-transcriptionally modified nucleoside pseudouridine in RNA by matrix-assisted laser desorption/ionization mass spectrometry.

K G Patteson et al.

Nucleic acids research, 29(10), E49-E49 (2001-05-23)

A new method using matrix-assisted laser desorption/ionization (MALDI) mass spectrometry for the direct analysis of the mass-silent post-transcriptionally modified nucleoside pseudouridine in nucleic acids has been developed. This method utilizes 1-cyclohexyl-3-(2-morpholinoethyl)carbodiimide to derivatize pseudouridine residues. After chemical derivatization all pseudouridine

Structure of the 5' nontranslated region of the coxsackievirus b3 genome: Chemical modification and comparative sequence analysis.

Jennifer M Bailey et al.

Journal of virology, 81(2), 650-668 (2006-11-03)

Coxsackievirus B3 (CVB3) is a picornavirus which causes myocarditis and pancreatitis and may play a role in type I diabetes. The viral genome is a single 7,400-nucleotide polyadenylated RNA encoding 11 proteins in a single open reading frame. The 5'

Matrix-assisted laser desorption/ionization mass spectrometry screening for pseudouridine in mixtures of small RNAs by chemical derivatization, RNase digestion and signature products.

Anita Durairaj et al.

Rapid communications in mass spectrometry : RCM, 22(23), 3727-3734 (2008-11-01)

We have developed a method to screen for pseudouridines in complex mixtures of small RNAs using matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS). First, the unfractionated crude mixture of tRNAs is digested to completion with an endoribonuclease, such as RNase T1

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