D0387
6,7-Dimethyl-5,6,7,8-tetrahydropterine hydrochloride
≥95%
Synonym(s):
2-Amino-6,7-dimethyl-4-hydroxy-5,6,7,8-tetrahydropteridine, DMPH4
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About This Item
Empirical Formula (Hill Notation):
C8H13N5O · HCl
CAS Number:
Molecular Weight:
231.68
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352100
MDL number:
Assay:
≥95%
Form:
powder
Quality Level
assay
≥95%
form
powder
storage temp.
−20°C
SMILES string
Cl[H].CC1Nc2nc(N)nc(O)c2NC1C
InChI
1S/C8H13N5O.ClH/c1-3-4(2)11-6-5(10-3)7(14)13-8(9)12-6;/h3-4,10H,1-2H3,(H4,9,11,12,13,14);1H
InChI key
GIHYTRGUZVYCQX-UHFFFAOYSA-N
Biochem/physiol Actions
Synthetic reduced pterin cofactor for nitric oxide synthetase, and for phenylalanine, tyrosine, and tryptophan hydroxylases; less active than the natural cofactor, tetrahydrobiopterin (BH4).
signalword
Danger
hcodes
Hazard Classifications
Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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V S Kudrin et al.
Biulleten' eksperimental'noi biologii i meditsiny, 91(5), 553-554 (1981-05-01)
Activity and KM of hypothalamic tyrosine hydroxylase (TH) were studied in rats preliminarily tested for predisposition to high ethanol consumption. It was shown that as regards cofactor of DMPH4 enzymatic reaction, KM of hypothalamic TH of animals with an initially
Ryotaro Hara et al.
AMB Express, 3(1), 70-70 (2013-12-11)
5-Hydroxy-l-tryptophan (5-HTP) is a naturally occurring aromatic amino acid present in the seeds of the African plant Griffonia simplicifolia. Although 5-HTP has therapeutic effects in various symptoms, efficient method of producing 5-HTP has not been established. In this study, we
I Jennings et al.
The Journal of biological chemistry, 265(4), 1885-1889 (1990-02-05)
BALB/c mice were immunized with a synthetic co-factor of the aromatic amino acid hydroxylases, 6,7-dimethyl-5,6,7,8-tetrahydropterin, conjugated to albumin. Hybridoma cell lines isolated from the immunized mice secreted monoclonal antibodies reacting specifically with the pterin molecule and monoclonal antibodies which were
Global Trade Item Number
| SKU | GTIN |
|---|---|
| D0387-100MG | 04061833284605 |