D0387
6,7-Dimethyl-5,6,7,8-tetrahydropterine hydrochloride
≥95%
Synonym(s):
2-Amino-6,7-dimethyl-4-hydroxy-5,6,7,8-tetrahydropteridine, DMPH4
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About This Item
Empirical Formula (Hill Notation):
C8H13N5O · HCl
CAS Number:
Molecular Weight:
231.68
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352100
MDL number:
Product Name
6,7-Dimethyl-5,6,7,8-tetrahydropterine hydrochloride, ≥95%
InChI
1S/C8H13N5O.ClH/c1-3-4(2)11-6-5(10-3)7(14)13-8(9)12-6;/h3-4,10H,1-2H3,(H4,9,11,12,13,14);1H
SMILES string
Cl[H].CC1Nc2nc(N)nc(O)c2NC1C
InChI key
GIHYTRGUZVYCQX-UHFFFAOYSA-N
assay
≥95%
form
powder
storage temp.
−20°C
Quality Level
Biochem/physiol Actions
Synthetic reduced pterin cofactor for nitric oxide synthetase, and for phenylalanine, tyrosine, and tryptophan hydroxylases; less active than the natural cofactor, tetrahydrobiopterin (BH4).
signalword
Danger
hcodes
Hazard Classifications
Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Dexamethasone and phenylalanine hydroxylase activities in rats.
G A Walsh et al.
Biochemical Society transactions, 18(2), 320-321 (1990-04-01)
S O Pember et al.
Biochemistry, 26(14), 4477-4483 (1987-07-14)
The interaction of pterin-dependent phenylalanine hydroxylase from Chromobacterium violaceum with the cofactor analogue 5-deaza-6-methyltetrahydropterin and the cofactor 6,7-dimethyltetrahydropterin (DMPH4) has been investigated by multifrequency electron spin resonance (ESR) spectroscopy. 5-Deaza-6-methyltetrahydropterin, which lacks the N-5 nitrogen present in the pyrazine ring
J T Cheng et al.
Neuroscience letters, 167(1-2), 117-120 (1994-02-14)
Neuropeptide Y (NPY) is found to be costored with norepinephrine (NE) in vesicles of the nerve terminals. Tyrosine hydroxylase (TH), the synthetic enzyme of NE, has been mentioned to be a rate-limiting step. In an attempt to understand the effect
Ryotaro Hara et al.
AMB Express, 3(1), 70-70 (2013-12-11)
5-Hydroxy-l-tryptophan (5-HTP) is a naturally occurring aromatic amino acid present in the seeds of the African plant Griffonia simplicifolia. Although 5-HTP has therapeutic effects in various symptoms, efficient method of producing 5-HTP has not been established. In this study, we
Reid M McCarty et al.
Biochemistry, 48(11), 2301-2303 (2009-02-24)
To elucidate the early steps required during biosynthesis of a broad class of 7-deazapurine-containing natural products, we have studied the reaction catalyzed by Escherichia coli QueD, a 6-pyruvoyl-5,6,7,8-tetrahydropterin synthase (PTPS) homologue possibly involved in queuosine biosynthesis. While mammalian PTPS homologues
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