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Merck
CN

D18609

1,3-Diamino-2-propanol

95%

Synonym(s):

2-Hydroxy-1,3-propanediamine, 1,3-Diamino-2-hydroxypropane

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About This Item

Linear Formula:
NH2CH2CH(OH)CH2NH2
CAS Number:
Molecular Weight:
90.12
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
EC Number:
210-474-2
Beilstein/REAXYS Number:
741859
MDL number:
Assay:
95%
Form:
solid
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InChI key

UYBWIEGTWASWSR-UHFFFAOYSA-N

InChI

1S/C3H10N2O/c4-1-3(6)2-5/h3,6H,1-2,4-5H2

SMILES string

NCC(O)CN

assay

95%

form

solid

mp

40-44 °C (lit.)

Quality Level

Gene Information

rat ... Grin2a(24409)

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Application

  • 1,3-Diamino-2-propanol is a versatile bidentate diamine ligand which is used in the synthesis of a variety of organometallic compounds.
  • It is a precursor to synthesize the fluorogenic dsDNA binder, N1,N3-bis(4-amidinophenyl)propane-1,3-diamine (BAPPA).
  • It can also be used as a branching unit in the synthesis of peptide dendrimers.

pictograms

Exclamation mark

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves


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Bis-4-aminobenzamidines: versatile, fluorogenic A/T-selective dsDNA binders.
Vazquez O, et al.
Organic Letters, 12(2), 216-219 (2009)
Syntheses, structures, and electrochemical properties of inclusion compounds of cucurbit [8] uril with cobalt (III) and nickel (II) complexes.
Mitkina T V, et al.
Inorganic Chemistry, 47(15), 6748-6755 (2008)
Synthesis and esterolytic activity of catalytic peptide dendrimers.
Lagnoux D, et al.
Chemistry?A European Journal , 10(5), 1215-1226 (2004)
Structure? activity relationships for cytotoxic ruthenium (II) arene complexes containing N, N-, N, O-, and O, O-chelating ligands.
Habtemariam A, et al.
Journal of Medicinal Chemistry, 49(23), 6858-6868 (2006)
Y W Hu et al.
Canadian journal of physiology and pharmacology, 60(12), 1493-1498 (1982-12-01)
The effect of diaminopropanol, an inhibitor of polyamine synthesis, on the metabolic response of liver to insulin was studied in streptozotocin-diabetic rats. Insulin elicited a prompt and very marked increase in ornithine and S-adenosylmethionine decarboxylase activities and in putrescine concentration.

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