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D204307

Diphenylacetic acid

Name: Diphenylacetic acid
Brand: ALDRICH

99%

Synonym(s):

α,α-Diphenylacetic acid, α-Phenylbenzeneacetic acid, 2,2-Diphenylacetic acid, Diphenylethanoic acid

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About This Item

Linear Formula:

(C₆H₅)₂CHCO₂H

CAS Number:

117-34-0

Molecular Weight:

212.24

UNSPSC Code:

12352100

NACRES:

NA.22

PubChem Substance ID:

24893604

EC Number:

204-185-0

Beilstein/REAXYS Number:

1910978

MDL number:

MFCD00004251

Assay:

99%

Form:

powder

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Properties

Quality Level

100

assay

99%

form

powder

mp

146-149 °C, 147-149 °C (lit.)

SMILES string

OC(=O)C(c1ccccc1)c2ccccc2

InChI

1S/C14H12O2/c15-14(16)13(11-7-3-1-4-8-11)12-9-5-2-6-10-12/h1-10,13H,(H,15,16)

InChI key

PYHXGXCGESYPCW-UHFFFAOYSA-N

Description

Application

Diphenylacetic acid can be used as a reagent in the kinetic resolution of racemic 2-hydroxy-γ-butyrolactones and 1-heteroarylalkanols by asymmetric esterification in the presence of pivalic anhydride and chiral acyl-transfer catalyst.
It can also be used as:

An additive in the ortho-arylation of 1-phenyl-β-carbolines using various aryl halides in the presence of ruthenium catalyst.
A catalyst to synthesize 2-allyl-3-oxazolin-5-one derivatives via Rh-catalyzed coupling reaction of azlactones and alkynes followed by aza-Cope rearrangement.

pictograms

GHS07

signalword

Warning

hcodes

H302,H319,H412

pcodes

P264 - P270 - P273 - P280 - P301 + P312 - P305 + P351 + P338

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Chronic 3 - Eye Irrit. 2

Storage Class

11 - Combustible Solids

wgk

WGK 2

flash_point_f

383.5 °F - closed cup

flash_point_c

195.3 °C - closed cup

ppe

Eyeshields, Gloves, type N95 (US)

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Ru(II)-Catalyzed β-Carboline Directed C-H Arylation and Isolation of Its Cycloruthenated Intermediates.

Subramani Rajkumar et al.

The Journal of organic chemistry, 80(11), 5532-5545 (2015-04-11)

A Ru(II)-catalyzed C-H arylation approach has been developed utilizing β-carboline alkaloids as the directing group. Selective formations of diarylated products from moderate to excellent yields were accomplished. Broad substrate scope with excellent functional group tolerance for C1-phenyl/thienyl/PAHs-β-carbolines was demonstrated. X-ray

Battacin-Inspired Ultrashort Peptides: Nanostructure Analysis and Antimicrobial Activity.

Hugh D Glossop et al.

Biomacromolecules, 20(7), 2515-2529 (2019-05-31)

Peptides can serve as versatile therapeutics with a highly modular structure and tunable biophysical properties. In particular, the efficacy of peptide antibiotics against drug-resistant pathogens is of great promise, as few new classes of antibiotics are being developed to overcome

Kinetic Resolution of Racemic 1-Heteroarylalkanols by Asymmetric Esterification Using Diphenylacetic Acid with Pivalic Anhydride and a Chiral Acyl-transfer Catalyst

Shiina I, et al.

Chemistry Letters (Jpn), 40(2), 147-149 (2011)

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Global Trade Item Number

SKU	GTIN
D204307-100G	04061833561416
D204307-5G	04061833561423
D204307-500G	04061831835731