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D26202

3,5-Diamino-1,2,4-triazole

Name: 3,5-Diamino-1,2,4-triazole
Brand: ALDRICH

98%

Synonym(s):

Guanazole

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About This Item

Empirical Formula (Hill Notation):

C₂H₅N₅

CAS Number:

1455-77-2

Molecular Weight:

99.09

UNSPSC Code:

12352100

NACRES:

NA.22

PubChem Substance ID:

24893699

EC Number:

215-937-2

Beilstein/REAXYS Number:

112467

MDL number:

MFCD00005233

Assay:

98%

Form:

solid

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Properties

Quality Level

200

assay

98%

form

solid

mp

202-205 °C (lit.)

SMILES string

Nc1n[nH]c(N)n1

InChI

1S/C2H5N5/c3-1-5-2(4)7-6-1/h(H5,3,4,5,6,7)

InChI key

PKWIYNIDEDLDCJ-UHFFFAOYSA-N

Description

General description

3,5-Diamino-1,2,4-triazole, also known as Guanazole is a heterocyclic compound and is commonly used as a building block in the synthesis of gallium complexes of tert-butyl-substituted acyclic and cyclic compounds. It is also being investigated as a corrosion inhibitor for copper.

Application

Inhibitor of DNA synthesis.

pictograms

GHS08,GHS09

signalword

Warning

hcodes

H361fd,H373,H411

pcodes

P202 - P260 - P273 - P280 - P308 + P313 - P391

Hazard Classifications

Aquatic Chronic 2 - Repr. 2 - STOT RE 2

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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A series of N-carbamoyloxyurea resistant cell lines with alterations in ribonucleotide reductase: lack of coordination in pyrimidine and purine reductase activity.

R G Hards et al.

Canadian journal of biochemistry and cell biology = Revue canadienne de biochimie et biologie cellulaire, 61(2-3), 120-129 (1983-02-01)

N-Carbamoyloxyurea is cytotoxic for cells in culture and, like hydroxyurea and guanazole, the drug is an effective inhibitor of mammalian ribonucleotide reductase and thus DNA synthesis. In addition to ribonucleotide reductase, N-carbamoyloxyurea has a second site of action which also

Schedule-dependency assessments of ribonucleoside diphosphate reductase inhibitors when used in combination with platinum compounds plus cyclophosphamide in the treatment of advanced L1210 leukemia.

G R Gale et al.

Cancer treatment reports, 63(3), 449-456 (1979-03-01)

Each of three ribonucleoside diphosphate reductase inhibitors was used as a third drug in combination with selected antitumor platinum (Pt) agents and cyclophosphamide (CY) in the treatment of advanced L1210 leukemia in C57BL/6 x DBA/2 mice. Each was synergistic with

Effect of iron-chelating agents on inhibitors of ribonucleotide reductase.

J G Cory et al.

Biochemical pharmacology, 30(9), 979-984 (1981-05-01)

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Global Trade Item Number

SKU	GTIN
D26202-100G	04061838353856
D26202-25G	04061833562444