D5057
Dipropylenetriamine NONOate
Synonym(s):
3,3′-(Hydroxynitrosohydrazino)bis-1-propanamine, DPTA NONOate
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About This Item
Empirical Formula (Hill Notation):
C6H17N5O2
CAS Number:
Molecular Weight:
191.23
UNSPSC Code:
12352116
PubChem Substance ID:
MDL number:
form
liquid
shipped in
dry ice
storage temp.
−70°C
SMILES string
NCCCN(CCCN)N(O)N=O
InChI
1S/C6H17N5O2/c7-3-1-5-10(6-2-4-8)11(13)9-12/h13H,1-8H2
InChI key
OHUBVPQNFCHIBG-UHFFFAOYSA-N
Application
t1/2 NO release = 300 min (phosphate buffer at 22°C)
Biochem/physiol Actions
NO donor
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
Storage Class
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
Regulatory Information
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Jonathan L Robinson et al.
PLoS computational biology, 9(5), e1003049-e1003049 (2013-05-10)
Nitric oxide (NO•) is generated by the innate immune response to neutralize pathogens. NO• and its autoxidation products have an extensive biochemical reaction network that includes reactions with iron-sulfur clusters, DNA, and thiols. The fate of NO• inside a pathogen
Jennifer S Stancill et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 318(5), R1004-R1013 (2020-04-16)
Both reactive nitrogen and oxygen species (RNS and ROS), such as nitric oxide, peroxynitrite, and hydrogen peroxide, have been implicated as mediators of pancreatic β-cell damage during the pathogenesis of autoimmune diabetes. While β-cells are thought to be vulnerable to
Graziela M Zanini et al.
Journal of neuroinflammation, 8, 66-66 (2011-06-09)
Cerebral malaria (CM) is a lethal complication of Plasmodium falciparum infections. In the Plasmodium berghei ANKA (PbA) murine model, CM is associated with marked brain inflammation, increased expression of endothelial cell adhesion molecules and leukocyte and platelet accumulation in brain