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D7881

Sigma-Aldrich

meso-2,3-Dimercaptosuccinic acid

~98%

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Synonym(s):
2,3-Dithio-meso-tartaric acid, DIM-SA, DMS, DMSA, Succimer
Linear Formula:
HO2CCH(SH)CH(SH)CO2H
CAS Number:
304-55-2
Molecular Weight:
182.22
Beilstein:
1725150
EC Number:
206-155-2
MDL number:
MFCD00064799
PubChem Substance ID:
57654130
NACRES:
NA.22

Assay

~98%

Quality Level

200

form

powder

mp

196-198 °C (dec.) (lit.)

storage temp.

−20°C

SMILES string

OC(=O)[C@@H](S)[C@@H](S)C(O)=O

InChI

1S/C4H6O4S2/c5-3(6)1(9)2(10)4(7)8/h1-2,9-10H,(H,5,6)(H,7,8)/t1-,2+

InChI key

ACTRVOBWPAIOHC-XIXRPRMCSA-N

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Application

meso-2,3-Dimercaptosuccinic acid (DMSA) has been used to form a monolayer on Mg/Ti/Au micromotors to enhance the chelation of toxic heavy metal contaminants (Zn(II), Cd(II) and Pb(II)) from polluted aqueous solutions.
It can be used:
  • As a reducing and stabilizing agent to synthesize monolayer-protected gold clusters.
  • For terminal carboxylation of the oleylamine coated Fe3O4 nanoparticles, to develop targeted curcumin drug delivery system.

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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One-pot preparation of subnanometer-sized gold clusters via reduction and stabilization by meso-2, 3-dimercaptosuccinic acid.
Negishi Y and Tsukuda T
Journal of the American Chemical Society, 125(14), 4046-4047 (2003)
Superparamagnetic Fe3O4 nanoparticles: synthesis by a solvothermal process and functionalization for a magnetic targeted curcumin delivery system.
Qi M, et al.
New. J. Chem., 40(5), 4480-4491 (2016)
Francesca Brero et al.
Nanomaterials (Basel, Switzerland), 10(10) (2020-10-01)
A combination of carbon ions/photons irradiation and hyperthermia as a novel therapeutic approach for the in-vitro treatment of pancreatic cancer BxPC3 cells is presented. The radiation doses used are 0-2 Gy for carbon ions and 0-7 Gy for 6 MV
Self-propelled chelation platforms for efficient removal of toxic metals.
Uygun DA, et al.
Environmental science. Nano, 3(3), 559-566 (2016)
Thanasis Chouliaras et al.
Membranes, 9(12) (2019-12-11)
Polymeric (ionic liquid) (PIL) copolymers bearing cationic imidazolium pendants and polar acrylic acid groups (P(VBCImY-co-AAx)), which both favor the interaction with CO2 molecules, have been synthesized and blended with film forming, high glass transition temperature aromatic polyether-based pyridinium PILs (PILPyr).
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