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E50000

Ethyl trifluoroacetate

Name: Ethyl trifluoroacetate
Brand: ALDRICH

99%

Synonym(s):

Trifluoroacetic acid ethyl ester

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About This Item

Linear Formula:

CF₃COOC₂H₅

CAS Number:

383-63-1

Molecular Weight:

142.08

UNSPSC Code:

12352100

NACRES:

NA.22

PubChem Substance ID:

24894596

EC Number:

206-851-6

Beilstein/REAXYS Number:

1761411

MDL number:

MFCD00000419

Assay:

99%

Form:

liquid

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Properties

Quality Level

200

assay

99%

form

liquid

refractive index

n20/D 1.307 (lit.)

bp

60-62 °C (lit.)

density

1.194 g/mL at 25 °C (lit.)

SMILES string

CCOC(=O)C(F)(F)F

InChI

1S/C4H5F3O2/c1-2-9-3(8)4(5,6)7/h2H2,1H3

InChI key

STSCVKRWJPWALQ-UHFFFAOYSA-N

Description

Application

Ethyl trifluoroacetate can be used:

To synthesize cyclopentenones or furans containing trifluoromethyl group from aromatic ynones.
In the selective trifluoroacetylation of anilines catalyzed by 4-dimethylaminopyridine.
As a starting material in the two-step electrosynthesis of trifluoroacetyltrimethylsilane (CF₃COSiMe₃).
In the preparation of trifluoromethyl ketones via trifluoroacetic ester/ketone metathesis with alkyl aryl ketones.
To synthesize o-fluorinated trifluoro acetophenones from substituted fluorobenzene.

signalword

Danger

Storage Class

3 - Flammable liquids

flash_point_f

30.2 °F - closed cup

flash_point_c

-1 °C - closed cup

ppe

Eyeshields, Faceshields, Gloves

Hazard Classifications

Eye Irrit. 2 - Flam. Liq. 2

Regulatory Information

危险化学品

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Highly selective trifluoroacetic ester/ketone metathesis: an efficient approach to trifluoromethyl ketones and esters

Zhou Y, et al.

Tetrahedron, 70(31), 4668-4674 (2014)

Non-defluorinative electrochemical silylation of ethyl trifluoroacetate: a practical synthesis of trifluoroacetyltrimethylsilane via its ethyltrimethylsilyl ketal

Bordeau M, et al.

Tetrahedron Letters, 44(19), 3741-3744 (2003)

Efficient chemoenzymatic synthesis of uridine 5'-diphosphate N-acetylglucosamine and uridine 5'-diphosphate N-trifluoacetyl glucosamine with three recombinant enzymes.

Xiaoyan Li et al.

Preparative biochemistry & biotechnology, 47(9), 852-859 (2016-05-26)

Uridine 5'-diphosphate N-acetylglucosamine (UDP-GlcNAc) is a natural UDP-monosaccharide donor for bacterial glycosyltransferases, while uridine 5'-diphosphate N-trifluoacetyl glucosamine (UDP-GlcNTFA) is its synthetic mimic. The chemoenzymatic synthesis of UDP-GlcNAc and UDP-GlcNTFA was attempted by three recombinant enzymes. Recombinant N-acetylhexosamine 1-kinase was used

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Global Trade Item Number

SKU	GTIN
1040031000	04022536046174
252549-100ML	04061837886225
252549-1L	04061837886249
252549-2.5L	04061837889943
252549-4L	04061837886263
252549-4X100ML	04061837886270
252549-500ML	04061837886294
252549-6X1L	04061837886317
252549-6X500ML	04061825973449
15512-1L-R	04061838741912
15512-2.5L-R	04061838125125
47608-250ML-F	04061832362038
47608-1L-F	04061832362021
11-0720-5-500ML-J	04061837741012
11-0730-5-500ML-J	04061837741029