F4043
Fisetin
≥98%
Synonym(s):
3,3′,4′,7-Tetrahydroxyflavone, 5-Deoxyquercetin, Natural Brown 1
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About This Item
Empirical Formula (Hill Notation):
C15H10O6 · xH2O
CAS Number:
Molecular Weight:
286.24 (anhydrous basis)
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352100
Colour Index Number:
75620
EC Number:
208-434-4
MDL number:
Beilstein/REAXYS Number:
292829
assay
≥98%
mp
>330 °C (lit.)
storage temp.
−20°C
SMILES string
O.Oc1ccc2C(=O)C(O)=C(Oc2c1)c3ccc(O)c(O)c3
InChI
1S/C15H10O6.H2O/c16-8-2-3-9-12(6-8)21-15(14(20)13(9)19)7-1-4-10(17)11(18)5-7;/h1-6,16-18,20H;1H2
InChI key
GYHFUROKCOMWNQ-UHFFFAOYSA-N
Gene Information
human ... CDC2(983), CDK5(1020), CDK6(1021), CYP1A2(1544), GSK3A(2931)
mouse ... Hexa(15211)
rat ... Il4(287287), Tnf(24835)
General description
Fisetin is a dietary flavonoid found in many fruits and vegetables. It is shown to exhibit anti-cancer, anti-inflammatory, antioxidant activities and also enhance the memory.
Application
Fisetin can be used:
- To prepare its iron metal complexes possessing promising antioxidant activity.
- In the study of its interaction with cyclodextrins (α and β) using analytical tools.
Fisetin is a naturally occurring therapeutically active flavonol which has been used in the synthesis of pharmaceutically active anti-inflammatory, anticonvulsant and antiproliferative agents.
Other Notes
Brown pigment found in many species of woody plants
Storage Class
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Giuseppe Sciamanna et al.
Cell reports, 31(7), 107644-107644 (2020-05-21)
Firing activity of external globus pallidus (GPe) is crucial for motor control and is severely perturbed in dystonia, a movement disorder characterized by involuntary, repetitive muscle contractions. Here, we show that GPe projection neurons exhibit a reduction of firing frequency
Xu Sun et al.
International journal of molecular medicine, 42(2), 811-820 (2018-05-12)
Fisetin, a natural flavonoid found in a variety of edible and medical plants, has been suggested to inhibit the proliferation of various tumor cells and to induce apoptosis. However, the effects of fisetin on breast cancer have rarely been reported
Suppressive effects of flavonoid fisetin on lipopolysaccharide-induced microglial activation and neurotoxicity.
Zheng, Long Tai and Ock, Jiyeon and Kwon, Byoung-Mog and Suk, Kyoungho
International Immunopharmacology, 8(3), 484-494 (2008)