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F505

Fisetin

Name: Fisetin
Brand: ALDRICH

Synonym(s):

3,3′,4′,7-Tetrahydroxyflavone, 5-Deoxyquercetin, Natural Brown 1

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About This Item

Empirical Formula (Hill Notation):

C₁₅H₁₀O₆ · xH₂O

CAS Number:

345909-34-4

Molecular Weight:

286.24 (anhydrous basis)

EC Number:

208-434-4

UNSPSC Code:

12352100

PubChem Substance ID:

24894880

Beilstein/REAXYS Number:

292829

MDL number:

MFCD04220857

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Properties

mp

>330 °C (lit.)

SMILES string

O.Oc1ccc2C(=O)C(O)=C(Oc2c1)c3ccc(O)c(O)c3

InChI

1S/C15H10O6.H2O/c16-8-2-3-9-12(6-8)21-15(14(20)13(9)19)7-1-4-10(17)11(18)5-7;/h1-6,16-18,20H;1H2

InChI key

GYHFUROKCOMWNQ-UHFFFAOYSA-N

Gene Information

human ... CDC2(983), CDK5(1020), CDK6(1021), CYP1A2(1544), GSK3A(2931)
mouse ... Hexa(15211)
rat ... Il4(287287), Tnf(24835)

Description

Storage Class

13 - Non Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

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The inhibitory effect of intravesical fisetin against bladder cancer by induction of p53 and down-regulation of NF-kappa B pathways in a rat bladder carcinogenesis model.

Jing Li et al.

Basic & clinical pharmacology & toxicology, 115(4), 321-329 (2014-03-22)

Intravesical chemotherapy after transurethral resection has been widely used as an adjuvant therapy to prevent recurrence and progression of superficial bladder cancer. Due to the insufficiency of the current chemotherapeutics, there is an urgent need to search for more novel

A plant flavonoid fisetin induces apoptosis in colon cancer cells by inhibition of COX2 and Wnt/EGFR/NF-kappaB-signaling pathways.

Yewseok Suh et al.

Carcinogenesis, 30(2), 300-307 (2008-11-28)

Overexpression of cyclooxygenase 2 (COX2) and uncontrolled wingless and Int (Wnt)-signaling pathway have long been suggested to play crucial roles in colorectal cancer. Studies show that selective COX2 inhibitors possess great potential as chemopreventive agents for colon cancer. Recent studies

In-vitro anti-proliferative and anti-oxidant activity of galangin, fisetin and quercetin: role of localization and intermolecular interaction in model membrane.

Ragini Sinha et al.

European journal of medicinal chemistry, 79, 102-109 (2014-04-15)

Flavonols are an important class of naturally occurring molecules and are known for their pharmacological activity. The activity is associated with the ability of flavonols to influence membrane-dependent processes. We have investigated the in-vitro anti-proliferative and anti-oxidant activity of galangin

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