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Merck
CN

G6503

Glycine ethyl ester hydrochloride

99%, for peptide synthesis

Synonym(s):

GEE, Ethyl glycinate hydrochloride

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About This Item

Linear Formula:
NH2CH2COOC2H5 · HCl
CAS Number:
623-33-6
Molecular Weight:
139.58
NACRES:
NA.22
PubChem Substance ID:
24895258
eCl@ss:
32160406
UNSPSC Code:
12352209
EC Number:
210-787-4
MDL number:
MFCD00012871
Beilstein/REAXYS Number:
3594034

Key Documents

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Product Name

Glycine ethyl ester hydrochloride, 99%

InChI

1S/C4H9NO2.ClH/c1-2-7-4(6)3-5;/h2-3,5H2,1H3;1H

InChI key

TXTWXQXDMWILOF-UHFFFAOYSA-N

SMILES string

Cl.CCOC(=O)CN

assay

99%

form

powder or chunks

reaction suitability

reaction type: solution phase peptide synthesis

technique(s)

drug transporter assay: suitable

color

white

mp

145-146 °C (lit.)

application(s)

peptide synthesis

Quality Level

200

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Application

Glycine ethyl ester (GEE) is used in conjunction with N-(3-Dimethylaminopropyl)-N′-ethylcarbodiimide (EDC) for carboxyl-footprinting studies of proteins. The GEE/EDC protocol effects specific derivatization of glutamate and aspartate carboxyl side chains on intact proteins. This reaction is readily done under aqueous conditions at physiological pH.

pictograms

Corrosion
GHS05

signalword

Danger

hcodes

H318

Hazard Classifications

Eye Dam. 1

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
SDBB5722
STBK9792
STBK3653
STBJ4141
STBJ2840

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Hao Zhang et al.
International journal of mass spectrometry, 312, 78-86 (2012-03-13)
Protein structure determines function in biology, and a variety of approaches have been employed to obtain structural information about proteins. Mass spectrometry-based protein footprinting is one fast-growing approach. One labeling-based footprinting approach is the use of a water-soluble carbodiimide, 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide
Zhang, H.; et al.
Molecular and Cellular Proteomics, 10 (2011)
Karen Leffondre et al.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 30(8), 1237-1243 (2014-10-19)
The most commonly used methods to investigate risk factors associated with renal function trajectory over time include linear regression on individual glomerular filtration rate (GFR) slopes, linear mixed models and generalized estimating equations (GEEs). The objective of this study was
Shane Darke et al.
Addictive behaviors, 50, 78-83 (2015-06-27)
The study aimed to determine long-term alcohol use patterns and correlates amongst heroin users. Longitudinal cohort. 11-year post-baseline follow-up of the Australian Treatment Outcome Study cohort. At 11-year follow-up, 431 (70%) participants were interviewed. Alcohol was used in the preceding
Michael N Okal et al.
Malaria journal, 14, 250-250 (2015-06-20)
Choice egg-count bioassays are a popular tool for analysing oviposition substrate preferences of gravid mosquitoes. This study aimed at improving the design of two-choice experiments for measuring oviposition substrates preferences of the malaria vector Anopheles gambiae senso lato, a mosquito
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