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H21101

4-Hydroxyphenylacetonitrile

Name: 4-Hydroxyphenylacetonitrile
Brand: ALDRICH

98%

Synonym(s):

4-Hydroxybenzyl cyanide

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About This Item

Linear Formula:

HOC₆H₄CH₂CN

CAS Number:

14191-95-8

Molecular Weight:

133.15

UNSPSC Code:

12352100

NACRES:

NA.22

PubChem Substance ID:

24895500

EC Number:

238-046-0

Beilstein/REAXYS Number:

1934470

MDL number:

MFCD00002383

Assay:

98%

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Properties

Quality Level

100

assay

98%

bp

330 °C/756 mmHg (lit.)

mp

67-70 °C (lit.)

SMILES string

Oc1ccc(CC#N)cc1

InChI

1S/C8H7NO/c9-6-5-7-1-3-8(10)4-2-7/h1-4,10H,5H2

InChI key

AYKYOOPFBCOXSL-UHFFFAOYSA-N

Description

pictograms

GHS07

signalword

Warning

hcodes

H302

pcodes

P301 + P312 + P330

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Dopamine beta-hydroxylase. Inactivation by a suicide substrate.

J M Baldoni et al.

The Journal of biological chemistry, 255(19), 8987-8990 (1980-10-10)

Dopamine beta-hydroxylase (EC 1.14.17.1) is inactivated by p-hydroxybenzylcyanide (PHBC) in a manner characteristic of a suicide substrate. The inactivation 1) is first order in inhibitor (Kd = 1.9 mM, k2 = 0.05 min-1, pH 5.0), 2) exhibits saturation kinetics, and

Alternate substrates of dopamine beta-hydroxylase. III. Stoichiometry of the inactivation reaction with benzyl cyanides and spectroscopic investigations.

G Colombo et al.

The Journal of biological chemistry, 259(3), 1607-1615 (1984-02-10)

Dopamine beta-hydroxylase was incubated with p-hydroxybenzyl cyanide, ascorbate, and O2 and the products of the hydroxylation reaction were monitored by high performance liquid chromatography. At early times, p-hydroxymandelonitrile was the sole product but this compound slowly decomposed to p-hydroxybenzaldehyde and

Tyrosinase kinetics: failure of the auto-activation mechanism of monohydric phenol oxidation by rapid formation of a quinomethane intermediate.

C J Cooksey et al.

The Biochemical journal, 333 ( Pt 3), 685-691 (1998-07-25)

When 3,4-dihydroxybenzylcyanide (DBC) is oxidized by mushroom tyrosinase, the first visible product, identified as the corresponding quinomethane, exhibits an absorption maximum at 480 nm. Pulse-radiolysis experiments, in which the o-quinone is formed by disproportionation of semiquinone radicals generated by single-electron

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Global Trade Item Number

SKU	GTIN
H21101-5G	04061832765990
H21101-25G	04061832765983