H5518
Hematoporphyrin
≥45%
Synonym(s):
8,13-Bis(1-hydroxyethyl)-3,7,12,17-tetramethyl-21H,23H-porphine-2,18-dipropionic acid
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About This Item
Empirical Formula (Hill Notation):
C34H38N4O6
CAS Number:
Molecular Weight:
598.69
PubChem Substance ID:
UNSPSC Code:
12352300
EC Number:
238-450-7
MDL number:
Beilstein/REAXYS Number:
78957
SMILES string
CC(O)c1c(C)c2cc3[nH]c(cc4nc(cc5[nH]c(cc1n2)c(C)c5CCC(O)=O)c(CCC(O)=O)c4C)c(C)c3C(C)O
concentration
≥45%
storage temp.
−20°C
Disclaimer
Readily dehydrates to monohydroxyethylmonovinyldeuteroporphyrin
Storage Class
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Mohammed Ahmed et al.
Indian journal of biochemistry & biophysics, 51(3), 175-187 (2014-09-11)
Interaction of proteins with small molecules is important in understanding delivery and transport of different therapeutic agents, including drugs. In the present study, we investigated the interaction between hematoporphyrin (HP), the principal component of photosensitizing drug with bovine serum albumin
Ilaria Postiglione et al.
International journal of molecular sciences, 16(9), 20375-20391 (2015-09-08)
Photofrin/photodynamic therapy (PDT) at sub-lethal doses induced a transient stall in proteasome activity in surviving A549 (p53(+/+)) and H1299 (p53(-/-)) cells as indicated by the time-dependent decline/recovery of chymotrypsin-like activity. Indeed, within 3 h of incubation, Photofrin invaded the cytoplasm
Chu-I Lee et al.
Journal of cellular biochemistry, 116(9), 2074-2085 (2015-04-29)
Neuroblastoma is one of the most aggressive cancers and has a complex form of differentiation. We hypothesized that advanced cellular differentiation may alter the susceptibility of neuroblastoma to photodynamic treatment (PDT) and confer selective survival advantage. We demonstrated that hematoporphyrin
Min-Hua Chen et al.
Biomedical engineering online, 13, 118-118 (2014-08-21)
The combination of biliary stent with photodynamic and chemotherapy seemed to be a beneficial palliative treatment of unresectable cholangiocarcinoma. However, by intravenous delivery to the target tumor the distribution of the drug had its limitations and caused serious side effect
Albish K Paul et al.
Photochemistry and photobiology, 91(6), 1348-1355 (2015-10-24)
Synthesis, photophysical and metal ion recognition properties of a series of amino acid-linked free-base and Zn-porphyrin derivatives (5-9) are reported. These porphyrin derivatives showed favorable photophysical properties including high molar extinction coefficients (>1 × 10(5) m(-1) cm(-1) for the Soret
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