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H57807

4-Hydroxyquinazoline

Name: 4-Hydroxyquinazoline
Brand: ALDRICH

98%

Synonym(s):

4-Quinazolinol

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About This Item

Empirical Formula (Hill Notation):

C₈H₆N₂O

CAS Number:

491-36-1

Molecular Weight:

146.15

NACRES:

NA.22

PubChem Substance ID:

24895709

UNSPSC Code:

12352100

EC Number:

207-735-8

MDL number:

MFCD00511302

Assay:

98%

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Properties

Quality Level

100

assay

98%

mp

216-219 °C (lit.)

SMILES string

O=C1NC=Nc2ccccc12

InChI

1S/C8H6N2O/c11-8-6-3-1-2-4-7(6)9-5-10-8/h1-5H,(H,9,10,11)

InChI key

QMNUDYFKZYBWQX-UHFFFAOYSA-N

Gene Information

mouse ... Parp2(11546)

Description

pictograms

GHS07

signalword

Warning

hcodes

H302

pcodes

P301 + P312 + P330

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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Synthesis and in vitro antitumor activity of 4(3H)-quinazolinone derivatives with dithiocarbamate side chains.

Sheng-Li Cao et al.

Bioorganic & medicinal chemistry letters, 15(7), 1915-1917 (2005-03-23)

A series of 4(3H)-quinazolinone derivatives with dithiocarbamate side chains were synthesized and tested for their in vitro antitumor activity against human myelogenous leukemia K562 cells. Among them, (3,4-dihydro-2-methyl-4-oxoquinazolin-6-yl)methyl 4-(4-fluorophenyl)piperazine-1-carbodithioate 8q exhibited significant inhibitory activity against K562 cells with IC(50) value

Parallel solution phase synthesis of 3,6,7-4(3H)-quinazolinones and evaluation of their antitumor activities against human cancer.

Hao Wu et al.

Journal of combinatorial chemistry, 12(3), 346-355 (2010-03-04)

Three diversity points of 4(3H)-quinazolinone are introduced at the 3-, 6-, and 7-positions with an efficient parallel solution-phase synthetic method. A one-pot synthesis was developed that gave the key intermediate in high yield. Five hit compounds exhibit preferable activities against

Effect of poly(ADP-ribose) polymerase inhibitors on the ischemia-reperfusion-induced oxidative cell damage and mitochondrial metabolism in Langendorff heart perfusion system.

R Halmosi et al.

Molecular pharmacology, 59(6), 1497-1505 (2001-05-17)

Ischemia-reperfusion induces reactive oxygen species (ROS) formation, and ROS lead to cardiac dysfunction, in part, via the activation of the nuclear poly(ADP-ribose) polymerase (PARP, called also PARS and ADP-RT). ROS and peroxynitrite induce single-strand DNA break formation and PARP activation

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Global Trade Item Number

SKU	GTIN
H57807-5G	04061833799765