M1641
Methoxyphenamine hydrochloride
≥99%
Synonym(s):
2-Methoxy-N,α-dimethylbenzeneethanamine hydrochloride, NSC 65644
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About This Item
Empirical Formula (Hill Notation):
C11H17NO · HCl
CAS Number:
Molecular Weight:
215.72
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352100
EC Number:
226-993-2
MDL number:
Assay:
≥99%
InChI key
FGSJNNQVSUVTPW-UHFFFAOYSA-N
InChI
1S/C11H17NO.ClH/c1-9(12-2)8-10-6-4-5-7-11(10)13-3;/h4-7,9,12H,8H2,1-3H3;1H
SMILES string
Cl.CNC(C)Cc1ccccc1OC
assay
≥99%
drug control
regulated under CDSA - not available from Sigma-Aldrich Canada
Quality Level
Related Categories
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Weili Wei et al.
Respirology (Carlton, Vic.), 15(5), 830-836 (2010-06-16)
Sequential three-step empirical therapy is useful for the management of chronic cough. The purpose of this study was to evaluate the efficacy and safety of modified sequential three-step empirical therapy. Consecutive patients (n = 240) with chronic cough were recruited
R T Coutts et al.
Drug metabolism and disposition: the biological fate of chemicals, 22(5), 756-760 (1994-09-01)
Metabolism of methoxyphenamine (MP) was conducted in vitro using commercially available microsomes prepared from human AHH-1 TK+/-cells in which CYP2D6 had been expressed. This study has confirmed the involvement of CYP2D6 in the metabolism of MP to O-desmethylmethoxyphenamine (ODMP) and
S D Roy
Xenobiotica; the fate of foreign compounds in biological systems, 20(1), 55-70 (1990-01-01)
1. Methoxyphenamine (MP) was metabolized in vitro by rat liver preparations to O-desmethylmethoxyphenamine (O-desmethyl-MP), N-desmethylmethoxyphenamine (N-desmethyl-MP) and 5-hydroxymethoxyphenamine (5-hydroxy-MP). These metabolic pathways were inhibited by SKF 525-A and carbon monoxide, which indicates that these reactions were mediated at least partly
G Muralidharan et al.
Xenobiotica; the fate of foreign compounds in biological systems, 19(2), 189-197 (1989-02-01)
1. Lewis and Dark Agouti (DA) rat strains (n = 4), models of human extensive and poor metabolizer phenotypes of debrisoquine/sparteine, respectively, were dosed with methoxyphenamine with and without prior administration of quinidine. Methoxyphenamine and its three metabolites, namely N-desmethylmethoxyphenamine
A Guttman
Electrophoresis, 16(10), 1900-1905 (1995-10-01)
A systematic approach is described for methods development of chiral separations of weak acidic and basic compounds by capillary electrophoresis, using several natural and derivatized neutral cyclodextrins as chiral selectors. Following the methods development scheme suggested here, the appropriate pH
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