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M81101

mono-Methyl hydrogen succinate

Name: mono-Methyl hydrogen succinate
Brand: ALDRICH

95%

Synonym(s):

Monomethyl succinate, Succinic acid monomethyl ester

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About This Item

Linear Formula:

CH₃OCOCH₂CH₂COOH

CAS Number:

3878-55-5

Molecular Weight:

132.11

UNSPSC Code:

12352100

NACRES:

NA.22

PubChem Substance ID:

24897222

EC Number:

223-408-2

Beilstein/REAXYS Number:

1722669

MDL number:

MFCD00002788

Assay:

95%

Form:

powder

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Properties

Quality Level

200

assay

95%

form

powder

bp

151 °C/20 mmHg (lit.)

mp

54-57 °C (lit.)

SMILES string

COC(=O)CCC(O)=O

InChI

1S/C5H8O4/c1-9-5(8)3-2-4(6)7/h2-3H2,1H3,(H,6,7)

InChI key

JDRMYOQETPMYQX-UHFFFAOYSA-N

Description

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Nitric oxide donors decrease the function and survival of human pancreatic islets.

D L Eizirik et al.

Molecular and cellular endocrinology, 118(1-2), 71-83 (1996-04-19)

Nitric oxide (NO) has been proposed as a possible mediator of beta-cell damage in human IDDM. This hypothesis is based on in vitro studies with rodent pancreatic islets. In the present study we examined whether human beta-cells are affected by

Differential effects of hyperlipidemia on insulin secretion in islets of langerhans from hyperglycemic versus normoglycemic rats.

Isabelle Briaud et al.

Diabetes, 51(3), 662-668 (2002-03-02)

Chronic elevations in plasma levels of fatty acids (FAs) adversely affect pancreatic beta-cell function in type 2 diabetes. In vitro, we have previously shown that deleterious effects of prolonged exposure of isolated islets to FAs were dependent on the presence

Methyl succinate antagonises biguanide-induced AMPK-activation and death of pancreatic beta-cells through restoration of mitochondrial electron transfer.

S A Hinke et al.

British journal of pharmacology, 150(8), 1031-1043 (2007-03-07)

Two mechanisms have been proposed to explain the insulin-sensitising properties of metformin in peripheral tissues: (a) inhibition of electron transport chain complex I, and (b) activation of the AMP activated protein kinase (AMPK). However the relationship between these mechanisms and

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Global Trade Item Number

SKU	GTIN
M81101-100G	04061831836622
M81101-25G	04061831817751