N14204
4-(4-Nitrobenzyl)pyridine
98%
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About This Item
Empirical Formula (Hill Notation):
C12H10N2O2
CAS Number:
Molecular Weight:
214.22
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
EC Number:
214-108-2
Beilstein/REAXYS Number:
170877
MDL number:
Assay:
98%
Form:
crystals
InChI
1S/C12H10N2O2/c15-14(16)12-3-1-10(2-4-12)9-11-5-7-13-8-6-11/h1-8H,9H2
InChI key
MNHKUCBXXMFQDM-UHFFFAOYSA-N
SMILES string
[O-][N+](=O)c1ccc(Cc2ccncc2)cc1
assay
98%
form
crystals
mp
69-71 °C (lit.)
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Application
Used in tests for alkylating agents and in a spectroscopic method for phosgene determination.
Storage Class
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Use of 4-(nitrobenzyl)pyridine (4-NBP) to test mutagenic potential of slow-reacting epoxides, their corresponding olefins, and other alkylating agents.
J H Kim et al.
Bulletin of environmental contamination and toxicology, 49(6), 879-885 (1992-12-01)
Rafael Gómez-Bombarelli et al.
Chemical research in toxicology, 25(6), 1176-1191 (2012-04-07)
Alkylating agents are considered to be archetypal carcinogens. One suitable technique to evaluate the activity of alkylating compounds is the NBP assay. This method is based on the formation of a chromophore in the reaction between the alkylating agent and
Marina González-Pérez et al.
Chemical research in toxicology, 25(12), 2755-2762 (2012-11-23)
The chemical reactivity of the mutagenic epoxides (EP) propylene oxide (PO), 1,2-epoxybutane (1,2-EB), and cis- and trans-2,3-epoxybutane (cis- and trans-2,3-EB) with 4-(p-nitrobenzyl)pyridine (NBP), a bionucleophile model for S(N)2 alkylating agents with high affinity for the guanine-N7 position, was investigated kinetically.
K Futagami et al.
Journal of chromatography. B, Biomedical sciences and applications, 704(1-2), 369-373 (1998-03-28)
We developed a rapid and simple method for identifying 25 commonly used organophosphorus insecticides in human serum using high-performance thin-layer chromatography (HPTLC). These organophosphates were separated on plates with three different developing systems within 6-18 min and detected by means
A Hemminki et al.
Chemico-biological interactions, 93(1), 51-58 (1994-10-01)
1,2-Epoxy alkanes from C3 to C8 were reacted with DNA, deoxyguanosine and 4-(p-nitrobenzyl) pyridine (NBP). DNA was hydrolyzed at neutral pH to release 7-alkylguanines. The products were analyzed by HPLC. The epoxides reacted largely according to the chain length, shorter
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