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Merck
CN

N8141

4-Nitroquinoline N-oxide

≥98%

Synonym(s):

4-NQO, 4-Nitroquinoline 1-oxide

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About This Item

Empirical Formula (Hill Notation):
C9H6N2O3
CAS Number:
Molecular Weight:
190.16
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
EC Number:
200-281-1
Beilstein/REAXYS Number:
165756
MDL number:
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Product Name

4-Nitroquinoline N-oxide, ≥98%

InChI key

YHQDZJICGQWFHK-UHFFFAOYSA-N

InChI

1S/C9H6N2O3/c12-10-6-5-9(11(13)14)7-3-1-2-4-8(7)10/h1-6H

SMILES string

[O-][N+](=O)c1cc[n+]([O-])c2ccccc12

assay

≥98%

color

yellow to brown

mp

154-156 °C (lit.)

solubility

acetone: soluble, clear to hazy

storage temp.

−20°C

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Application

4-Nitroquinoline N-oxide has been used as a model compound to study its carcinogenic effects.

Biochem/physiol Actions

Skin and lung tumor initiator under experimental conditions.

General description

4-Nitroquinoline N-oxide is a quinoline derivative widely used in chemical research and development.

pictograms

Health hazard

signalword

Danger

hcodes

Hazard Classifications

Carc. 1B

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type P2 (EN 143) respirator cartridges


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Antitumor activity of ficus deltoidea extract on oral cancer: An in vivo study
Al-Koshab M, et al.
Journal of Oncology, 2020 (2020)
Interplay of DNA repair, homologous recombination, and DNA polymerases in resistance to the DNA damaging agent 4-nitroquinoline-1-oxide in Escherichia coli.
Williams AB, et al.
DNA Repair, 9(10), 1090-1097 (2010)
The antimutagenic effect of monoterpenes against UV-irradiation-, 4NQO-and t-BOOH-induced mutagenesis in coli.
Nikolic B, et al.
Archives of Biological Sciences, 63(1), 117-128 (2011)
Ye Du et al.
Environment international, 135, 105369-105369 (2019-12-17)
Effluents from wastewater treatment plants (WWTPs) may contain various pollutants with potential toxic effects. Ozonation is widely applied to purify wastewater, which may influence the toxicity and water quality indices simultaneously. The main goal of this study was to reveal
J Peter Svensson et al.
PloS one, 7(5), e37368-e37368 (2012-05-23)
Studies in Saccharomyces cerevisiae show that many proteins influence cellular survival upon exposure to DNA damaging agents. We hypothesized that human orthologs of these S. cerevisiae proteins would also be required for cellular survival after treatment with DNA damaging agents.

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Cancer research has revealed that the classical model of carcinogenesis, a three step process consisting of initiation, promotion, and progression, is not complete.

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