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P19906

Sigma-Aldrich

1-Phenylbiguanide hydrochloride

98%

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Linear Formula:
C6H5NHC(=NH)NHC(=NH)NH2·HCl
CAS Number:
55-57-2
Molecular Weight:
213.67
EC Number:
200-239-2
MDL number:
MFCD00035040
PubChem Substance ID:
24898259
NACRES:
NA.22

Assay

98%

form

powder

mp

244-247 °C (lit.)

SMILES string

Cl.NC(=N)NC(=N)Nc1ccccc1

InChI

1S/C8H11N5.ClH/c9-7(10)13-8(11)12-6-4-2-1-3-5-6;/h1-5H,(H6,9,10,11,12,13);1H

InChI key

FHUDRDSKZQDCBC-UHFFFAOYSA-N

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Y L Kuo et al.
Journal of applied physiology (Bethesda, Md. : 1985), 105(2), 611-620 (2008-06-07)
Sensitization of vagal lung C fibers has been postulated to contribute to the development of asthma, but support for this notion is still lacking. We investigated the characteristics and function of pulmonary C fibers (PCFs) in ovalbumin (OVA)-sensitized Brown Norway
Abhaya Dutta et al.
Pulmonary pharmacology & therapeutics, 25(5), 383-391 (2012-07-24)
Phenylbiguanide (PBG) and capsaicin evoke cardiorespiratory reflexes utilizing two separate pathways. It is known that Indian Red Scorpion (Mesobuthus tumulus; MBT) venom augments PBG (5-HT(3)) responses but, the effect of MBT venom on capsaicin (TRPV1)-induced response is not known. Therefore
Ramin Ataee et al.
Archives of Iranian medicine, 13(2), 120-125 (2010-03-02)
Serotonin (5HT) has been shown to be a mitogenic factor in several carcinomas. Its mitogenic effect is elicited through a wide range of 5HT receptor subtypes. In this study, the effects of 5HT, 5HT3 (1-phenylbiguanide hydrochloride) and 5HT4 (cisapride) agonists
Y Tsutsui et al.
Neuroscience, 157(3), 683-696 (2008-10-18)
The aims of the present study were to investigate whether the activation of the 5-HT receptor subtypes (5-HT(4) and 5-HT(3)) acted significantly on the modification of the tetrodotoxin-resistant sodium current (I(NaR)) in small-sized rat trigeminal ganglion (TG) neurons and whether
S Kanoo et al.
Acta physiologica (Oxford, England), 196(4), 365-373 (2009-01-13)
This study was performed to delineate the kinin (receptor)-dependent pathways in the Indian red scorpion (Mesobuthus tamulus; MBT) venom-induced pulmonary oedema as well as the augmentation of cardio-pulmonary reflexes evoked by phenyldiguanide (PDG). In urethane-anaesthetized adult rats, the effect of
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