P39001
Phthalazone
99%
Synonym(s):
Benzo[d]pyridazin-1(2H)one
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About This Item
Empirical Formula (Hill Notation):
C8H6N2O
CAS Number:
Molecular Weight:
146.15
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
EC Number:
204-319-8
Beilstein/REAXYS Number:
3654
MDL number:
Assay:
99%
Form:
powder
InChI
1S/C8H6N2O/c11-8-7-4-2-1-3-6(7)5-9-10-8/h1-5H,(H,10,11)
InChI key
IJAPPYDYQCXOEF-UHFFFAOYSA-N
SMILES string
O=C1NN=Cc2ccccc12
assay
99%
form
powder
mp
183-185 °C (lit.)
Quality Level
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Craig Zetterberg et al.
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The objective is to evaluate methoxsalen as an in vitro phenotyping tool in comparison to ABT as a nonspecific inactivator of P450 mediated metabolism. The reversible inhibition of methoxsalen and ABT against the P450, FMO, AO, MAO-A and -B, enzymes
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Takayuki Amano et al.
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Dantrolene is used for malignant hyperthermia during anesthesia, and it sometimes causes severe liver injury as a side effect. Dantrolene is metabolized to acetylaminodantrolene, which is formed via the reduction of dantrolene to aminodantrolene and subsequent acetylation. Formation of hydroxylamine
Shotaro Uehara et al.
Drug metabolism and disposition: the biological fate of chemicals, 45(8), 883-886 (2017-05-11)
Common marmosets (Callithrix jacchus), New World monkeys, are a promising primate model for preclinical drug metabolism studies because of the similarities of cytochrome P450 (P450) enzyme function to those of humans. Despite an increasing number of drug candidates catalyzed by
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