P4019
Brij® S20
Synonym(s):
Polyethylene glycol octadecyl ether, Polyoxyethylene (20) stearyl ether
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About This Item
Linear Formula:
C18H37(OCH2CH2)nOH, n~20
CAS Number:
MDL number:
UNSPSC Code:
12162002
PubChem Substance ID:
NACRES:
NA.23
form
solid
Quality Level
mp
44-46 °C (lit.)
HLB
15
SMILES string
CCCCCCCCCCCCCCCCCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO
InChI
1S/C20H41O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-19-22-20-18-21/h2-20H2,1H3
InChI key
PSEGVHKUPXNGGJ-UHFFFAOYSA-N
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General description
Brij® S20 is a surfactant that belongs to the class of polyoxyethylene ethers. It is majorly used in pharmaceutical applications to improve the solubility of the drugs. It can also be grafted on a variety of surfaces to enhance the intracellular uptake of dyes.
Application
- Nanostructured lipid carriers for oral delivery of silymarin: Improving its absorption and in vivo efficacy in type 2 diabetes and metabolic syndrome model.: This study utilizes Brij® S20 to develop nanostructured lipid carriers for oral delivery of silymarin. The findings demonstrate enhanced absorption and efficacy of silymarin in treating type 2 diabetes and metabolic syndrome, highlighting the potential of Brij® S20 in improving drug delivery systems. (Piazzini et al., 2019).
- Water-stable all-biodegradable microparticles in nanofibers by electrospinning of aqueous dispersions for biotechnical plant protection.: The study uses Brij® S20 to create water-stable, biodegradable microparticles in nanofibers through electrospinning. These microparticles are designed for biotechnical plant protection, demonstrating the potential of Brij® S20 in agricultural biotechnology. (Bansal et al., 2012).
Legal Information
Brij is a registered trademark of Croda International PLC
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 4 Oral
Storage Class Code
11 - Combustible Solids
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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Nanostructured lipid carriers as promising delivery systems for plant extracts: The case of silymarin
Piazzini V, et al.
Applied Sciences, 8(7), 1163-1163 (2018)
Brij-grafted-chitosan copolymers with function of P-glycoprotein modulation: Synthesis, characterization and in vitro investigations
Xiong W, et al.
Carbohydrate Polymers, 204, 89-96 (2019)
Wei Xiong et al.
International journal of nanomedicine, 13, 3781-3793 (2018-07-11)
Berberine (BBR) is a plant-derived benzylisoquinoline alkaloid and has been demonstrated to be a potential treatment for various chronic diseases. The poor water solubility and P-glycoprotein (Pgp)-mediated drug efflux are the main challenges for its further application in a clinical
J Q Zhang et al.
Drug delivery, 14(6), 381-387 (2007-08-19)
The study describes the development of stealth solid lipid nanoparticles (SLNs) as colloidal carriers for silibinin, a drug with very low solubility. Stealth SLNs were constituted mainly of bioacceptable and biodegradable lipids, such as stearic acid and surfactant Brij 78
S O Williams et al.
Drug development and industrial pharmacy, 26(1), 71-77 (2000-04-01)
The purpose of this study was to scale up an oil/water (o/w) cream formulation containing 40% diethylene glycol monoethyl ether (DGME), developed via 300-g laboratory batches in a 2(5-2) fractional factorial design, to 7-kg batch sizes in a Brogli-10 homogenizer.
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