Skip to Content
Merck
CN

P51559

Propionyl chloride

98%

Synonym(s):

Chloro ethyl ketone, Ethyl chloroform, Propionic acid chloride, Prorionyl chloride

Sign In to View Organizational & Contract Pricing

Select a Size

About This Item

Linear Formula:
CH3CH2COCl
CAS Number:
79-03-8
Molecular Weight:
92.52
Beilstein:
385632
EC Number:
201-170-0
MDL number:
MFCD00000745
UNSPSC Code:
12352100
PubChem Substance ID:
24898602
NACRES:
NA.22

Key Documents

View All Documentation
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

vapor density

3.2 (vs air)

Assay

98%

refractive index

n20/D 1.404 (lit.)

bp

77-79 °C (lit.)

mp

−94 °C

density

1.059 g/mL at 25 °C (lit.)

SMILES string

CCC(Cl)=O

InChI

1S/C3H5ClO/c1-2-3(4)5/h2H2,1H3

InChI key

RZWZRACFZGVKFM-UHFFFAOYSA-N

Looking for similar products? Visit Product Comparison Guide

General description

Propionyl chloride is an important chemical intermediate used to synthesize various propionic acid derivatives.

Application

Propionyl chloride can be used as an acylating agent:
  • To convert anisole to 4-methoxypropiophenone and 2-methoxynaphthalene to 1-propio-2-methoxynaphthalene in the presence of Indium(III) chloride (InCl3) impregnated mesoporous Si-MCM-41 catalyst.

It can also be used:
  • For chlorination in the presence of sulfuryl chloride and peroxides to form α-chloropropionyl chloride and β-chloropropionyl chloride.
  • In reaction with (hydroxypropyl)cellulose to form the propanoate ester, [(propionyloxy)propyl]cellulose.

Signal Word

Danger

Hazard Statements

H225,H302,H314,H331

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Eye Dam. 1 - Flam. Liq. 2 - Skin Corr. 1B

Supplementary Hazards

EUH014

Storage Class Code

3 - Flammable liquids

WGK

WGK 1

Flash Point(F)

42.8 °F - closed cup

Flash Point(C)

6 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

危险化学品
This item has

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
SDBB5627
0000185870
0000178015
0000178015
0000185870

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

The propanoate ester of (2-hydroxypropyl) cellulose: a thermotropic cholesteric polymer that reflects visible light at ambient temperatures
Tseng SL, et L.
Macromolecules, 15(5), 1262-1264 (1982)
Chlorinations with Sulfuryl Chloride. III.(a) The Peroxide-Catalyzed Chlorination of Aliphatic Acids and Acid Chlorides.(b) The Photochemical Sulfonation of Aliphatic Acids
Kharasch MS and Brown HC
Journal of the American Chemical Society, 62(4), 925-929 (1940)
Yu Duan et al.
Molecular medicine reports, 16(6), 9735-9740 (2017-10-19)
The aim of the present study was to report on a complete synthetic approach, namely benzylation-hydrolysis-acylation‑hydrogenation, to the synthesis of regioselectively acylated quercetin analogues using low‑cost rutin as a starting material. Three quercetin analogues, quercetin‑3‑O‑propionate (Q‑pr), quercetin‑3‑O‑butyrate (Q‑bu) and quercetin‑3‑O‑valerate
Douglas T Durig et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 60(7), 1481-1504 (2004-05-19)
Variable temperature (-60 to -100 degrees C) studies of the infrared spectra (3500-400 cm(-1)) of propionyl fluoride (CH3CH2CFO) and 2-methylpropionyl fluoride ((CH3)2CHCFO), dissolved in liquid xenon have been recorded. From these data, the enthalpy difference has been determined to be
Joanna Kurczewska et al.
International journal of pharmaceutics, 486(1-2), 226-231 (2015-04-07)
Vancomycin was immobilized on three different organically functionalized silicas. The materials obtained were used for a controlled release of the antibiotic. The influence of the type of chemical bond on the in vitro drug release was investigated. A weak ionic
View All Related Papers

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service