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P51559

Propionyl chloride

Name: Propionyl chloride
Brand: ALDRICH

98%

Synonym(s):

Chloro ethyl ketone, Ethyl chloroform, Propionic acid chloride, Prorionyl chloride

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About This Item

Linear Formula:

CH₃CH₂COCl

CAS Number:

79-03-8

Molecular Weight:

92.52

UNSPSC Code:

12352100

NACRES:

NA.22

PubChem Substance ID:

24898602

EC Number:

201-170-0

Beilstein/REAXYS Number:

385632

MDL number:

MFCD00000745

Assay:

98%

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Properties

vapor density

3.2 (vs air)

Quality Level

200

assay

98%

refractive index

n20/D 1.404 (lit.)

bp

77-79 °C (lit.)

mp

−94 °C

density

1.059 g/mL at 25 °C (lit.)

SMILES string

CCC(Cl)=O

InChI

1S/C3H5ClO/c1-2-3(4)5/h2H2,1H3

InChI key

RZWZRACFZGVKFM-UHFFFAOYSA-N

Description

General description

Propionyl chloride is an important chemical intermediate used to synthesize various propionic acid derivatives.

Application

Propionyl chloride can be used as an acylating agent:

To convert anisole to 4-methoxypropiophenone and 2-methoxynaphthalene to 1-propio-2-methoxynaphthalene in the presence of Indium(III) chloride (InCl₃) impregnated mesoporous Si-MCM-41 catalyst.

It can also be used:

For chlorination in the presence of sulfuryl chloride and peroxides to form α-chloropropionyl chloride and β-chloropropionyl chloride.
In reaction with (hydroxypropyl)cellulose to form the propanoate ester, [(propionyloxy)propyl]cellulose.

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pictograms

GHS02,GHS06,GHS05

signalword

Danger

hcodes

H225,H302,H314,H331

pcodes

P210 - P280 - P301 + P312 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Eye Dam. 1 - Flam. Liq. 2 - Skin Corr. 1B

supp_hazards

EUH014

Storage Class

3 - Flammable liquids

wgk

WGK 1

flash_point_f

42.8 °F - closed cup

flash_point_c

6 °C - closed cup

ppe

Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter

Regulatory Information

危险化学品

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Chlorinations with Sulfuryl Chloride. III.(a) The Peroxide-Catalyzed Chlorination of Aliphatic Acids and Acid Chlorides.(b) The Photochemical Sulfonation of Aliphatic Acids

Kharasch MS and Brown HC

Journal of the American Chemical Society, 62(4), 925-929 (1940)

The propanoate ester of (2-hydroxypropyl) cellulose: a thermotropic cholesteric polymer that reflects visible light at ambient temperatures

Tseng SL, et L.

Macromolecules, 15(5), 1262-1264 (1982)

Vancomycin-modified silica: Synthesis, controlled release and biological activity of the drug.

Joanna Kurczewska et al.

International journal of pharmaceutics, 486(1-2), 226-231 (2015-04-07)

Vancomycin was immobilized on three different organically functionalized silicas. The materials obtained were used for a controlled release of the antibiotic. The influence of the type of chemical bond on the in vitro drug release was investigated. A weak ionic

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Global Trade Item Number

SKU	GTIN
P51559-25G	04061834376385
P51559-500G	04061834376422