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Merck
CN

QBD10501

Azido-dPEG®4-NHS ester

Synonym(s):

3-(Azidotetra(ethyleneoxy))propionic acid succinimidyl ester, NHS-Peg4-Azide, Polyethylene glycol

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About This Item

Empirical Formula (Hill Notation):
C15H24N4O8
CAS Number:
944251-24-5
Molecular Weight:
388.37
NACRES:
NA.22
PubChem Substance ID:
329823930
UNSPSC Code:
12352108
MDL number:
MFCD13184948

Key Documents

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shipped in

ambient

storage temp.

−20°C

InChI

1S/C15H24N4O8/c16-18-17-4-6-24-8-10-26-12-11-25-9-7-23-5-3-15(22)27-19-13(20)1-2-14(19)21/h1-12H2

SMILES string

O=C(ON1C(CCC1=O)=O)CCOCCOCCOCCOCCN=[N+]=[N-]

InChI key

OIGKWPIMJCPGGD-UHFFFAOYSA-N

assay

>90%

form

solid or viscous liquid

reaction suitability

reaction type: click chemistry
reagent type: cross-linking reagent
reaction type: click chemistry

functional group

NHS ester
azide

polymer architecture

shape: linear
functionality: heterobifunctional

Related Categories

Features and Benefits

The azido-dPEG®4-NHS ester contains an azide function on one end of a single molecular weight dPEG® spacer (17.7 Å) and a reactive group on the other end of the spacer. The dPEG® spacer is hydrophilic and non-immunogenic and improves the water solubility of the target molecule while reducing the immunogenicity and increasing the hydrodynamic volume of the target. NHS ester readily reacts with amines in aqueous solution or organic solvent. The azide group reacts with an alkyne in the well-known click chemistry reaction. The click chemistry reaction proceeds by copper(I) or ruthenium catalysis or in a strain-catalyzed reaction with certain types of alkyne partners.

Legal Information

Products Protected under U.S. Patents # 7,888,536 B2
dPEG is a registered trademark of Quanta BioDesign

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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