QBD10505
Azido-dPEG®12-NHS ester
Synonym(s):
Polyethylene glycol
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About This Item
Empirical Formula (Hill Notation):
C31H56N4O16
Molecular Weight:
740.79
MDL number:
UNSPSC Code:
12352108
PubChem Substance ID:
NACRES:
NA.22
Assay
>90%
form
solid or viscous liquid
reaction suitability
reaction type: click chemistry
reagent type: cross-linking reagent
reaction type: click chemistry
polymer architecture
shape: linear
functionality: heterobifunctional
shipped in
ambient
storage temp.
−20°C
SMILES string
O=C(CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCN=[N+]=[N-])ON1C(CCC1=O)=O
InChI key
JSNJRDFOCXNHTB-UHFFFAOYSA-N
Features and Benefits
The azido-dPEG®12-NHS ester contains an azide function on one end of a single molecular weight dPEG® spacer (47.2 Å) and NHS ester group on the other end of the spacer. The dPEG® spacer is hydrophilic and non-immunogenic and improves the water solubility of the target molecule while reducing the immunogenicity and increasing the hydrodynamic volume of the target. N-hydroxysuccinimide (NHS) ester readily reacts with amines in aqueous solution or organic solvent. The azide group reacts with an alkyne in the well-known click chemistry reaction. The click chemistry reaction proceeds by copper(I) or ruthenium catalysis or in a strain-catalyzed reaction with certain types of alkyne partners.
Legal Information
Products Protected under U.S. Patents # 7,888,536 B2
dPEG is a registered trademark of Quanta BioDesign
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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