QTPDAMINE
QuicTPD™ Amine Screening Set
sustainability
Greener Alternative Product
greener alternative category
storage temp.
2-8°C
Related Categories
General description
QTPD Amine set comprised of 36 partial protacs plated in duplicate with rich linker diversity, architecture and length targeting Cereblon(CRBN) and von Hippel Lindau( VHL) E3 ligases ending in a amine terminal.
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Application
This set can be used for reacting with warheads/ligands for targets of interest with solvent exposed pendant carboxylic acid handles via peptide coupling reactions. Two distinct warheads can be reacted with this set to generate 72 distinct small molecule degraders that can be used for subsequent screening.
Features and Benefits
Representative set of partial protacs targeting both CRBN and VHL with typical PEG, hydrophobic and rigid linkers that can be used for construction of PROTACs. Customers can make screen upto 24 reaction conditions with this set and empty glass shell vials provided with the pre-plated set. Glass shell vials allow for exploration of reaction conditions tolerant to different, reagents, solvents and temperature. Miniaturized synthesis allows for reduction in solvent, reagent, water and energy usage making this a sustainable and faster route to PROTAC discovery.
Other Notes
QuicTPD Amine Screening Set
PROTAC Coupling Model Calculations available under the More Documents section below.
PROTAC Coupling Model Calculations available under the More Documents section below.
Legal Information
QuicTPD is a trademark of Merck KGaA, Darmstadt, Germany
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Repr. 1B - STOT RE 2
Target Organs
Blood
Storage Class Code
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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Accelerating PROTACs Discovery Through a Direct-to-Biology Platform Enabled by Modular Photoclick Chemistry
Yan KN, et.al
Advanced science (Weinheim, Baden-Wurttemberg, Germany), 11 (2024)
Direct-to-biology, automated, nano-scale synthesis, and phenotypic screening-enabled E3 ligase modulator discovery
Wang Z, et.al
Nature Communications, 14, 8437-8437 (2023)
Integrated Direct-to-Biology Platform for the Nanoscale Synthesis and Biological Evaluation of PROTACs
Stevens R, et.al
Journal of Medicinal Chemistry, 66, 15437-15452 (2023)
Direct-to-Biology Accelerates PROTAC Synthesis and the Evaluation of Linker Effects on Permeability and Degradation
Hendrick CE, et.al
ACS Medicinal Chemistry Letters, 13, 1182-1190 (2022)
Rebecca Stevens et al.
Journal of medicinal chemistry, 66(22), 15437-15452 (2023-11-07)
Proteolysis targeting chimeras (PROTACs) are heterobifunctional molecules that co-opt the cell's natural proteasomal degradation mechanisms to degrade undesired proteins. A challenge associated with PROTACs is the time and resource-intensive optimization; thus, the development of high-throughput platforms for their synthesis and
Articles
Discover QuicTPD™ Acid/Amine Screening Sets for rapid, high-throughput PROTAC® synthesis, streamlining targeted protein degradation research.
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
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