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R1102

4-Oxo-2-thioxo-3-thiazolidinylacetic acid

Name: 4-Oxo-2-thioxo-3-thiazolidinylacetic acid
Brand: ALDRICH

95%

Synonym(s):

Rhodanine-3-acetic acid

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About This Item

Empirical Formula (Hill Notation):

C₅H₅NO₃S₂

CAS Number:

5718-83-2

Molecular Weight:

191.23

EC Number:

227-220-1

UNSPSC Code:

12352100

PubChem Substance ID:

24899344

Beilstein/REAXYS Number:

149513

MDL number:

MFCD00005491

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Properties

assay

95%

mp

145-148 °C (lit.)

SMILES string

OC(=O)CN1C(=O)CSC1=S

InChI

1S/C5H5NO3S2/c7-3-2-11-5(10)6(3)1-4(8)9/h1-2H2,(H,8,9)

InChI key

JGRMXPSUZIYDRR-UHFFFAOYSA-N

Description

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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Synthesis of new chalcone derivatives containing a rhodanine-3-acetic acid moiety with potential anti-bacterial activity.

Zhen-Hua Chen et al.

European journal of medicinal chemistry, 45(12), 5739-5743 (2010-10-05)

With an intention to synergize the anti-bacterial activity of chalcones and rhodanine-3-acetic acid, several hybrid compounds possessing chalcone and rhodanine-3-acetic acid moieties were synthesized and tested for their anti-bacterial activity. Some compounds presented great anti-microbial activities against Gram-positive bacteria (including

SAR and 3D-QSAR studies on thiadiazolidinone derivatives: exploration of structural requirements for glycogen synthase kinase 3 inhibitors.

Ana Martinez et al.

Journal of medicinal chemistry, 48(23), 7103-7112 (2005-11-11)

The 2,4-disubstituted thiadiazolidinones (TDZD) are described as the first ATP-noncompetitive GSK-3 inhibitors. Following an SAR study about TDZD, different structural modifications in the heterocyclic ring aimed to test the influence of each heteroatom on the biological study are here reported