T14001
3,4,5,6-Tetrahydrophthalic anhydride
95%
Synonym(s):
Cyclohexene-1,2-dicarboxylic anhydride
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About This Item
Empirical Formula (Hill Notation):
C8H8O3
CAS Number:
Molecular Weight:
152.15
UNSPSC Code:
12162002
NACRES:
NA.23
PubChem Substance ID:
EC Number:
219-374-3
Beilstein/REAXYS Number:
136335
MDL number:
InChI key
HMMBJOWWRLZEMI-UHFFFAOYSA-N
InChI
1S/C8H8O3/c9-7-5-3-1-2-4-6(5)8(10)11-7/h1-4H2
SMILES string
O=C1OC(=O)C2=C1CCCC2
assay
95%
mp
69-73 °C (lit.)
Quality Level
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Related Categories
signalword
Danger
hcodes
Hazard Classifications
Aquatic Chronic 3 - Eye Dam. 1 - Resp. Sens. 1 - Skin Sens. 1
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Regulatory Information
危险化学品
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A Ikai et al.
The Journal of biological chemistry, 265(14), 8280-8284 (1990-05-15)
As a model for the molecular structure of proteins belonging to the alpha 2-macroglobulin family, ovomacroglobulin of reptilian origin was studied by electron microscopy in the original tetrameric form as well as in the dissociated forms into half- and quarter
J B Swaney
Journal of lipid research, 24(3), 245-252 (1983-03-01)
Trypsin digestion of human high density lipoprotein (d 1.125-1.21 g/ml) on which the lysine residues have been masked with the reversible blocking group, 2,3,4,5-tetrahydrophthallic anhydride (THPA), was found to result in the fragmentation of the apoA-I component, but not the
Subat Turdi et al.
Toxicology letters, 178(3), 197-201 (2008-05-10)
Doxorubicin is an effective anthracycline used for cancer therapy. However, the clinical application of doxorubicin has been largely limited by its irreversible cardiotoxicity, which is mainly induced by the primary amine group. In this study, we structurally modified doxorubicin by
[Data providing a basis for the MPEL of tetrahydrophthalic anhydride, tetrahydrophthalamide and hydroxymethyltetrahydrophthalimide in the air of the work environment].
A I Gurova et al.
Gigiena truda i professional'nye zabolevaniia, (12)(12), 37-38 (1985-12-01)
L I O'Connell et al.
Archives of biochemistry and biophysics, 263(2), 315-322 (1988-06-01)
Modification of glutamate dehydrogenase with 3,4,5,6-tetrahydrophthalic anhydride at pH 8.0 results in the progressive loss of enzymatic activity and a concomitant increase in the negative charge of the protein. Although the rate of inactivation at room temperature is too rapid
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