T34908
D-Thyroxine
99%
Synonym(s):
3,3′,5,5′-Tetraiodo-D-thyronine, 3-[4-(4-Hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]-D-alanine
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About This Item
Empirical Formula (Hill Notation):
C15H11I4NO4
CAS Number:
Molecular Weight:
776.87
PubChem Substance ID:
UNSPSC Code:
12352101
Beilstein/REAXYS Number:
2954910
MDL number:
SMILES string
N[C@H](Cc1cc(I)c(Oc2cc(I)c(O)c(I)c2)c(I)c1)C(O)=O
InChI
1S/C15H11I4NO4/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23/h1-2,4-5,12,21H,3,20H2,(H,22,23)/t12-/m1/s1
InChI key
XUIIKFGFIJCVMT-GFCCVEGCSA-N
assay
99%
mp
~235 °C (dec.)
Gene Information
human ... THRA(7067), THRB(7068)
Regulatory Information
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P L Canner et al.
Journal of the American College of Cardiology, 8(6), 1245-1255 (1986-12-01)
The Coronary Drug Project was conducted between 1966 and 1975 to assess the long-term efficacy and safety of five lipid-influencing drugs in 8,341 men aged 30 to 64 years with electrocardiogram-documented previous myocardial infarction. The two estrogen regimens and dextrothyroxine
G S Sandhu et al.
Magnetic resonance in medicine, 18(1), 237-243 (1991-03-01)
31P NMR spectroscopy was used to monitor the cardiac energy metabolism in hypothyroid rat hearts. Differential alterations in phosphocreatine and inorganic phosphate levels were observed upon treatment of hypothyroid animals with DT4 and LT4, while both agents were equipotent in
Purified D-thyroxine in athyreotic patients.
P Hamon et al.
Lancet (London, England), 341(8858), 1477-1477 (1993-06-05)
H Y Lin et al.
Journal of immunology (Baltimore, Md. : 1950), 161(2), 843-849 (1998-07-22)
We have investigated the mechanism by which thyroid hormone potentiates IFN-gamma-induced HLA-DR expression. IFN-gamma-induced HLA-DR expression requires activation of STAT1alpha and induction of the Class II trans-activator, CIITA. HeLa and CV-1 cells treated only with L-thyroxine (T4) demonstrated increased tyrosine
The diagnosis and management of hyperlipidemia.
A M Gotto et al.
Disease-a-month : DM, 32(5), 245-311 (1986-05-01)
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