T34908
D-Thyroxine
99%
Synonym(s):
3,3′,5,5′-Tetraiodo-D-thyronine, 3-[4-(4-Hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]-D-alanine
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About This Item
Empirical Formula (Hill Notation):
C15H11I4NO4
CAS Number:
Molecular Weight:
776.87
PubChem Substance ID:
UNSPSC Code:
12352101
Beilstein/REAXYS Number:
2954910
MDL number:
assay
99%
mp
~235 °C (dec.)
SMILES string
N[C@H](Cc1cc(I)c(Oc2cc(I)c(O)c(I)c2)c(I)c1)C(O)=O
InChI
1S/C15H11I4NO4/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23/h1-2,4-5,12,21H,3,20H2,(H,22,23)/t12-/m1/s1
InChI key
XUIIKFGFIJCVMT-GFCCVEGCSA-N
Gene Information
human ... THRA(7067), THRB(7068)
Regulatory Information
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Rational drug therapy of the hyperlipoproteinemias, Part II.
C B Blum et al.
Rational drug therapy, 20(10), 1-4 (1986-10-01)
F Parker
Journal of the American Academy of Dermatology, 13(1), 1-30 (1985-07-01)
The ability to recognize diverse clinical forms of xanthomas, such as tuberous, planar, eruptive and tendinous, is important in the detection of underlying systemic disease. A variety of primary genetic disorders, as well as numerous secondary conditions such as diabetes
R Narihara et al.
Neurochemistry international, 25(5), 451-454 (1994-11-01)
The effects of thyroxine and its related derivatives on gamma-aminobutyric acid (GABA) receptors in the rat brain were examined. D-Thyroxine strongly inhibited [3H]flunitrazepam binding to benzodiazepine receptor in crude synaptic membrane from the rat brain. The Scatchard analysis of the