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Merck
CN

330022S

Avanti

WR304 mAb-biotinylated

Avanti Research™ - A Croda Brand

Synonym(s):

WR304 mAb-biotinylated, WR304 Mouse Monoclonal Antibody (IgM), Biotinylated Anti-(PIP/PIP2), 1X TBS (Tris Buffered Saline)

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About This Item

UNSPSC Code:
12352211
NACRES:
NA.45

Key Documents

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Product Name

WR304 mAb-biotinylated, Avanti Research™ - A Croda Brand 330022S

antibody form

purified immunoglobulin

antibody product type

primary antibodies

Assay

>95%

form

solution

packaging

pkg of 1 × 0.1 mL (polypropylene tube with screw cap (330022S-25ug))

manufacturer/tradename

Avanti Research™ - A Croda Brand 330022S

concentration

0.25 mg/mL (330022S-25ug)

shipped in

dry ice

storage temp.

−70°C

General description

The 3-sn-phosphatidylinositol-4-phosphate (PIP) and lipid A adjuvant, are component of WR304. WR304 mAb-biotinylated antibody was developed by the Walter Reed Army Institute of Research (WRAIR).
WR304 is an antibody that binds specifically to the lipids PIP and PIP2. WR304 also neutralizes infectious HIV-1 virus and can be used to probe the presence of PIP and PIP2 in membranes in a variety of applications including inositol phosphate-dependent cell signaling pathways. WR304-Biotin allows this antibody to be used in combination with a wide range of commercially available streptavidin-fluorophore and streptavidin-enzyme complexes. WR304-Biotin can also be used with samples that contain mouse IgM.This antibody was developed by the Walter Reed Army Institute of Research (WRAIR) using a targeted adjuvant protocol with liposomes containing Avanti′s Lipid A.

Biochem/physiol Actions

WR304 is an antibody that binds specifically to the lipids 3-sn-phosphatidylinositol-4-phosphate (PIP) and PIP2. WR304 neutralizes infectious human immunodeficiency virus (HIV-1 virus). WR304 interacts with sulfatide and not with neutral glycolipids. It is effective in neutralizing human peripheral blood mononuclear cells (PBMC) associated infections. WR304 can be used to probe the presence of PIP and PIP2 in membranes in a variety of applications including inositol phosphate-dependent cell signaling pathways. WR304-Biotin allows this antibody to be used in combination with a wide range of commercially available streptavidin-fluorophore and streptavidin-enzyme complexes. WR304-Biotin can also be used with samples that contain mouse IgM.

Packaging

0.5 mL Polypropylene Tube with Screw Cap (330022S-25ug)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

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Storage Class Code

10 - Combustible liquids

WGK

nwg

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Lipid binding properties of 4E10, 2F5, and WR304 monoclonal antibodies that neutralize HIV-1
Matyas GR, et al.
Biochimica et Biophysica Acta - Biomembranes, 1788(3), 660-665 (2009)
Gary R Matyas et al.
Biochimica et biophysica acta, 1788(3), 660-665 (2008-12-23)
Two human mAbs (2F5 and 4E10), originally derived from HIV-1-infected patients, are important, but rare, mAbs that exhibit broad cross-clade neutralizing activities against HIV-1. In addition to peptide sequences on the gp41 envelope protein, both antibodies reportedly also bound specifically
Zoltan Beck et al.
Biochemical and biophysical research communications, 354(3), 747-751 (2007-01-30)
The binding characteristics of two monoclonal antibodies (mAb) to phosphatidylinositol-4-phosphate (PIP) were examined: a murine IgM mAb to PIP; and a human IgG mAb (4E10) that binds both to HIV-1 envelope protein and also to neutral and anionic phospholipids, including
N M Wassef et al.
Molecular immunology, 21(10), 863-868 (1984-10-01)
Monoclonal antibodies against phosphatidylinositol phosphate were produced after injecting a mouse with liposomes containing dimyristoylphosphatidylcholine, cholesterol, phosphatidylinositol phosphate and lipid A. The antibodies raised were IgM (kappa) and their activities were assayed by complement-dependent damage to liposomes lacking lipid A
Bruce K Brown et al.
Journal of virology, 81(4), 2087-2091 (2006-12-08)
Both a murine monoclonal antibody to phosphatidylinositol phosphate (PIP) and a human monoclonal antibody (4E10) that is known to have broadly neutralizing capabilities against primary isolates of human immunodeficiency virus type 1 (HIV-1) bound to PIP, as determined by enzyme-linked

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