550001P
Avanti
Aurora™-DSG
Avanti Research™ - A Croda Brand
Synonym(s):
Gold-Lipid Conjugate; 1,2-distearoyl-sn-glycero-3-(Aurora Nanoparticle)
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About This Item
Empirical Formula (Hill Notation):
Au55C262H265P12NO7
Molecular Weight:
14744.75
UNSPSC Code:
12352211
NACRES:
NA.25
Product Name
Aurora™-DSG, Aurora™-DSG Nanoparticles, powder
Assay
>95% (TLC)
form
powder
packaging
pkg of 1 × 500 μg (with screw cap)
manufacturer/tradename
Avanti Research™ - A Croda Brand 550001P
shipped in
wet ice
storage temp.
2-8°C
General description
This new conjugate from Avanti consists of an Aurora™ gold cluster capped with triphenylphosphine ligands and a single diglyceride ligand. Fifty-five gold atom nanoparticles, first described by Schmid, are fascinating structures that are commonly used for contrast agents in various imaging applications. Ideally this particle, unlike larger colloidal style particles, is less intrusive to the target application and behaves like an organic entity instead of a foreign metallic probe. They also are a great generic platform for bottom up synthesis of novel, gold-centered nanostructures due to the ease and completeness of ligand exchange reactions. This complex is readily visible under TEM and can also be viewed in optical microscopes if further processed using a silver development procedure.
Biochem/physiol Actions
Aurora™-DSG (Distearoylglycerol) nanoparticles aid in improving contrast in liposome and membrane preparations in cryo-transmission microscopy imaging. They are useful in lipid research as they provide good resolution image of the lipid bilayer on incorporation. Their biophysical interaction with lipid bilayers is exploited in many membrane research studies. Confocal, atomic force and high-resolution microscopy utilize the incorporation of Aurora™ into the heterogeneous bilayers, as they do not hamper the lipid layer properties and composition.
Packaging
5 mL PTFE Vial with Screw Cap (550001P-500ug)
Legal Information
Aurora is a trademark of Avanti Polar Lipids, LLC
Avanti Research is a trademark of Avanti Polar Lipids, LLC
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Eye Dam. 1 - Skin Sens. 1 - STOT RE 1 Inhalation
Target Organs
Central nervous system,Peripheral nervous system
Storage Class Code
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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Jesús Sot et al.
Chemistry and physics of lipids, 218, 40-46 (2018-12-07)
Lipid bilayers of different phospholipid compositions have been prepared, in the form of vesicles, or of supported lipid bilayers, and doped with Aurora™ at 0.1 mol%. Aurora™ consists of an Au55 gold nanoparticle (about 1.4 nm in diameter) capped with triphenylphosphine ligands
Valentina Marchesano et al.
ACS nano, 7(3), 2431-2442 (2013-03-02)
Gold nanoparticles have emerged as novel safe and biocompatible tools for manifold applications, including biological imaging, clinical diagnostics, and therapeutics. The understanding of the mechanisms governing their interaction with living systems may help the design and development of new platforms
Chie Kojima et al.
Methods in enzymology, 464, 131-145 (2009-11-12)
Liposomes have been widely used as drug carriers. Visible liposomes have recently become more attractive as drug carriers in personalized medicine. Gold nanoparticles (Au NPs) have unique size- and shape-dependent properties based on their surface plasmon resonance. They can be
Miao Li et al.
Nano letters, 15(1), 770-775 (2014-12-17)
The controlled injection of nanoscopic objects into living cells with light offers promising prospects for the development of novel molecular delivery strategies or intracellular biosensor applications. Here, we show that single gold nanoparticles from solution can be patterned on the
Wiktor Lewandowski et al.
Langmuir : the ACS journal of surfaces and colloids, 29(10), 3404-3410 (2013-02-21)
Hybrid structures made of metal nanoparticles with liquid crystalline coating attract considerable attention due to their conspicuous self-assembly and potential synergistic properties. Here we report on a new structural parameter that can be used to control the formation of hybrid
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