640010P
Avanti
DMABA-d10 NHS Ester
Avanti Research™ - A Croda Brand
Synonym(s):
4-(dimethylamino)benzoic acid N-hydroxysuccinimide ester-d10
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About This Item
Empirical Formula (Hill Notation):
C13H4D10N2O4
CAS Number:
Molecular Weight:
272.32
UNSPSC Code:
12352211
description
4-[di(methyl-d3)amino]-2,5-dioxo-1-pyrrolidinyl ester benzoic-2,3,5,6-d4 acid
Assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 1 mg (640010P-1mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand
shipped in
dry ice
storage temp.
−20°C
SMILES string
O=C(ON(C(CC1)=O)C1=O)C2=C([2H])C([2H])=C(N(C([2H])([2H])[2H])C([2H])([2H])[2H])C([2H])=C2[2H]
General description
The DMABA NHS ester reagents were developed by Dr. Robert Murphy′s laboratory at the University of Colorado in order to create PE derivatives where all subclasses and potentially oxidized products could be universally detected using a common precursor ion in the positive ion mode by Mass Spectrometry.
Biochem/physiol Actions
DMABA-d10 NHS Ester, deuterium enriched 10-(dimethylamino) benzoic acid (DMABA) N-hydroxysuccinimide (NHS) ester reagent (d10) is used for derivatizing the primary amine group of PE lipids for differential labeling. It is useful in lipid research. Structurally it has 6 hydrogen atoms deuterated in the 2 methyl groups and 4 hydrogen atoms deuterated in the aromatic ring. d10-DMABA NHS enables detection of phosphatidylethanolamine subclasses in biological samples by tandem mass spectrometry.
Packaging
5 mL Amber Glass Screw Cap Vial (640010P-1mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
Storage Class Code
11 - Combustible Solids
Regulatory Information
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Gilbert O Fruhwirth et al.
Biochimica et biophysica acta, 1772(7), 718-736 (2007-06-16)
Oxidized lipids are generated from (poly)unsaturated diacyl- and alk(en)ylacyl glycerophospholipids under conditions of oxidative stress. The great variety of reaction products is defined by the degree of modification, hydrophobicity, chemical reactivity, physical properties and biological activity. The biological activities of
Yukiko Ueda et al.
Nutrition research (New York, N.Y.), 28(4), 239-244 (2008-12-17)
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Karin A Zemski Berry et al.
Analytical chemistry, 81(16), 6633-6640 (2010-03-27)
A set of four (D(0), D(4), D(6), and D(10)) deuterium enriched 4-(dimethylamino)benzoic acid (DMABA) N-hydroxysuccinimide (NHS) ester reagents was developed that react with the primary amine group of glycerophosphoethanolamine (PE) lipids to create derivatives where all subclasses of DMABA labeled
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