700079P
Avanti
zymosterone
Avanti Research™ - A Croda Brand
Synonym(s):
cholesta-8(9),24-dien-3-one
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About This Item
Empirical Formula (Hill Notation):
C27H42O
CAS Number:
Molecular Weight:
382.62
UNSPSC Code:
12352211
NACRES:
NA.25
Assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 1 mg (700079P-1mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand
shipped in
dry ice
storage temp.
−20°C
SMILES string
C[C@]1(CC2)C(CCC3=C1CC[C@@]4(C)C3CCC4[C@@H](CCC=C(C)C)C)CC2=O
InChI
1S/C27H42O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,19-20,23-24H,6,8-17H2,1-5H3/t19-,20?,23?,24?,26+,27-/m1/s1
InChI key
AUNLIRXIJAVBNM-ZSFXRWSJSA-N
Biochem/physiol Actions
Zymosterone is metabolized to cholesterol synthesis intermediate, zymosterol in the presence of enzyme hydroxysteroid (17β) dehydrogenase 7 (HSD17B7). Zymosterone conversion to zymosterol catalyzed by 3-keto sterol reductase (ERG27) is a key step in yeast ergosterol biosynthesis.
Packaging
5 mL Amber Glass Screw Cap Vial (700079P-1mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
Storage Class Code
11 - Combustible Solids
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Thomas Ohnesorg et al.
Journal of molecular endocrinology, 37(1), 185-197 (2006-08-12)
In both humans and mice, 17beta-hydroxysteroid dehydrogenase type-7 (HSD17B7) was described as possessing dual enzymatic functionality. The enzyme was first shown to be able to convert estrone to estradiol in vitro. Later involvement of this enzyme in postsqualene cholesterol biosynthesis
Heli Jokela et al.
Endocrinology, 151(4), 1884-1892 (2010-02-27)
Hydroxysteroid (17beta) dehydrogenase 7 (HSD17B7) has been shown to catalyze the conversion of both estrone to estradiol (17-ketosteroid reductase activity) and zymosterone to zymosterol (3-ketosteroid reductase activity involved in cholesterol biosynthesis) in vitro. To define the metabolic role of the
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