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700132P

Avanti

3β,7α,25-trihydroxy-5-cholestenoic acid

Avanti Polar Lipids 700132P, powder

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Synonym(s):
cholest-5-en-26-oic acid, 3β,7α,25-trihydroxy
Empirical Formula (Hill Notation):
C27H44O5
CAS Number:
2192191-62-9
Molecular Weight:
448.64
NACRES:
NA.25

Assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 1 mg (700132P-1mg)

manufacturer/tradename

Avanti Polar Lipids 700132P

shipped in

dry ice

storage temp.

−20°C

SMILES string

O[C@H](C1)CC[C@](C1=C[C@H]2O)(C)C3C2C(CC[C@@H]4[C@H](C)CCCC(C)(O)C(O)=O)[C@]4(C)CC3

General description

3β,7α,25-trihydroxy-5-cholestenoic acid is synthesized from 3β, 25-dihydroxy-5-cholestenoic acid in the presence of enzyme 25-hydroxycholesterol 7α-hydroxylase (CYP7B1). It is also synthesized from 7α,25-dihydroxycholesterol by the action of enzyme sterol 27-hydroxylase (CYP27A1).

Biochem/physiol Actions

3β,7α,25-trihydroxy-5-cholestenoic acid is used in the synthesis of 7α,25-dihydroxy-3-oxocholest-4-en-26-oic acid by using cholesterol oxidase.

Packaging

5 mL Amber Glass Screw Cap Vial (700132P-1mg)

Storage Class Code

11 - Combustible Solids

Regulatory Information

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{Identification of 7{alpha
Abdel-Khalik J, et al.
Biochimie, 153, 86-86 (2018)
William J Griffiths et al.
Free radical biology & medicine, 134, 42-52 (2018-12-24)
Using liquid chromatography - mass spectrometry in combination with derivatisation chemistry we profiled the oxysterol and cholestenoic acid content of cerebrospinal fluid from patients with Alzheimer's disease (n = 21), vascular dementia (n = 11), other neurodegenerative diseases (n = 15, Lewy bodies dementia, n = 3, Frontotemporal

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