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700149P

Avanti

16:0 cholesteryl-d7 ester

Avanti Polar Lipids 700149P, powder

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Synonym(s):
cholesteryl-d7 palmitate
Empirical Formula (Hill Notation):
C43H69D7O2
CAS Number:
1416275-32-5
Molecular Weight:
632.11
NACRES:
NA.25

Assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 10 mg (700149P-10mg)
pkg of 1 × 25 mg (700149P-25mg)

manufacturer/tradename

Avanti Polar Lipids 700149P

shipped in

dry ice

storage temp.

−20°C

General description

Cholesteryl palmitate is a cholesteryl ester. 16:0 cholesteryl-d7 ester is the deuterated form of cholesteryl palmitate or 16:0 cholesteryl ester.

Application

16:0 cholesteryl-d7 ester has been used:
  • in plasma sample preparation for tandem mass spectrometry analysis (MS/MS)
  • as an internal standard in mass spectrometry for quantification of nerve lipids from mice
  • as an internal standard in time-of-flight mass spectrometry (TOFMS) for the quantification of serum extracellular vesicles (EVs) lipids
  • as an external calibrator and internal spiking standard in tandem mass spectroscopy measurements
  • in liposome preparation for retinyl ester hydrolase (REH) and cholesteryl esterase activity assay

Biochem/physiol Actions

Cholesteryl palmitate is associated with atherosclerotic plaque. Deuterated cholesteryl palmitate in used in reconstituting high-density lipoprotein (HDL). An elevated levels of the ratio of cholesteryl oleate to cholesteryl palmitate is implicated with apoptotic cell death in the atherosclerotic lesions.

Packaging

5 mL Amber Glass Screw Cap Vial (700149P-10mg)
5 mL Amber Glass Screw Cap Vial (700149P-25mg)

also commonly purchased with this product

Product No.
Description
Pricing

Storage Class Code

11 - Combustible Solids

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Michael S Gardner et al.
Journal of the American Society for Mass Spectrometry, 28(11), 2319-2329 (2017-08-13)
We demonstrate the application of in-source nitrogen collision-induced dissociation (CID) that eliminates the need for ester hydrolysis before simultaneous analysis of esterified cholesterol (EC) and triglycerides (TG) along with free cholesterol (FC) from human serum, using normal phase liquid chromatography
Suming Chen et al.
Journal of circulating biomarkers, 8, 1849454419879848-1849454419879848 (2019-10-22)
There is a wide variety of extracellular vesicles (EVs) that differ in size and cargo composition. EVs isolated from human plasma or serum carry lipid, protein, and RNA cargo that provides insights to the regulation of normal physiological processes, and
Y I Parmar et al.
The Journal of biological chemistry, 258(3), 2000-2004 (1983-02-10)
Reconstituted high density lipoprotein has been prepared by sonication and preparative ultracentrifugation of mixtures containing the apoprotein of high density lipoprotein, egg phosphatidylcholine, cholesteryl oleate, and acyl chain deuterated cholesteryl palmitate in aqueous buffer. The resulting structures have a size
Y Zang et al.
Journal of dairy science, 102(2), 1224-1236 (2018-11-26)
Co-supplementation of methyl donors may lower hepatic lipid content in transition cows. To define the ability of methyl donor supplementation (MDS) to reduce hepatic lipid content and modify the plasma lipidome, 30 multiparous Holstein cows (2.04 ± 0.69 lactations; 689
Maidina Tuohetahuntila et al.
The Journal of biological chemistry, 292(30), 12436-12448 (2017-06-16)
Activation of hepatic stellate cells (HSCs) is a critical step in the development of liver fibrosis. During activation, HSCs lose their lipid droplets (LDs) containing triacylglycerols (TAGs), cholesteryl esters, and retinyl esters (REs). We previously provided evidence for the presence
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