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Merck
CN

790413C

Avanti

Coag Reagent II

Avanti Research™ - A Croda Brand

Synonym(s):

Coag Reagent II, Coagulation Reagent II, contains DOPC:DOPS (7:3, w/w)

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About This Item

UNSPSC Code:
12352211
NACRES:
NA.25

Key Documents

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Product Name

Coag Reagent II, Avanti Research™ - A Croda Brand 790413C

form

liquid

packaging

pkg of 1 × 2.5 mL (790413C-25mg)
pkg of 2 × 4 mL (790413C-200mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand 790413C

concentration

10 mg/mL (790413C-25mg)
25 mg/mL (790413C-200mg)

application(s)

microbiology

lipid type

phospholipids

shipped in

dry ice

storage temp.

−20°C

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General description

Coag Reagent II synthetic has the phospholipids 1,2-dioleoyl-sn-glycero-3-phosphocholine(DOPC) and 1,2-dioleoyl-sn-glycero-3-[phospho-l-serine] (DOPS) in the ratio 7:3w/w.

Application

Coag Reagent II may be used:
  • in preparation of liposomes for liposome mechanical properties determination
  • as a component of solubilization and crystallization buffer for the chemokine receptor CCR5, in large unilamellar vesicles (LUVs) preparation for cyclooxygenase (COX1 and COX-2) incorporation
  • in equilibration of chip coated with anti-glutathione-S-transferase (GST) antibody for surface plasmon resonance (SPR) binding assay

Biochem/physiol Actions

1,2-dioleoyl-sn-glycero-3-phosphocholine(DOPC) and 1,2-dioleoyl-sn-glycero-3-[phospho-l-serine] (DOPS) mimics biological membranes of endosomes and exosomes and is useful in drug delivery.

Packaging

5 mL Clear Glass Sealed Ampule (790413C-200mg)
5 mL Clear Glass Sealed Ampule (790413C-25mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

Signal Word

Danger

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3

Target Organs

Central nervous system

Storage Class Code

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

WGK

WGK 3

Flash Point(F)

does not flash

Flash Point(C)

does not flash

Regulatory Information

易制毒化学品（2类）
危险化学品
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Fast, efficient reconstitution of the cyclooxygenases into proteoliposomes
MirAfzali Z, et al.
Archives of Biochemistry and Biophysics, 443(1-2), 60-65 (2005)
Direct macromolecular drug delivery to cerebral ischemia area using neutrophil-mediated nanoparticles
Zhang C, et al.
Theranostics, 7(13), 3260-3260 (2017)
A biosensor-based approach toward purification and crystallization of G protein-coupled receptors
Navratilova I, et al.
Analytical biochemistry, 353(2), 278-283 (2006)
Membrane lipid co-aggregation with alpha-synuclein fibrils
Hellstrand E, et al.
Testing, 8(10), 3260-3260 (2013)
Kathleen Allen Rodowicz et al.
Chemistry and physics of lipids, 163(8), 787-793 (2010-09-25)
Quantification of the mechanical properties of liposomes is critical in helping to predict their behavior during various applications such as targeted drug delivery, response to mechanical characterization or their interactions with isolated cytoskeletal elements. A numerical implementation of the Evans

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