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791641C

Avanti

15:0-18:1-d7-PI

Avanti Polar Lipids

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Synonym(s):
1-pentadecanoyl-2-oleoyl(d7)-sn-glycero-3-phosphoinositol (ammonium salt)
Empirical Formula (Hill Notation):
C42H75D7NO13P
CAS Number:
2260669-44-9
Molecular Weight:
847.12
NACRES:
NA.25

Assay

>99% (TLC)

form

liquid

packaging

pkg of 1 × 1 mL (791641C-1mg)

manufacturer/tradename

Avanti Polar Lipids

concentration

1 mg/mL (791641C-1mg)

shipped in

dry ice

storage temp.

−20°C

General description

15:0-18:1-d7-PI (1-pentadecanoyl-2-oleoyl(d7)-sn-glycero-3-phosphoinositol) is a deuterated phospholipid. The lipid comprises the phosphotidylinositol attached to pentadecanoic acid and oleic acid. Oleic acid harbors the deuterium ions. Phosphotidylinositol are esterified inositol associated with bacteria and eukaryotes. It is synthesized in endoplasmic reticulum and is an anionic lipid. The sn-1 and sn-2 positions of the glycerol is esterified with fatty acids. The phosphate group is present in sn-3 position.
This deuterium labeled lipid is also available in a formulation of multiple lipid standards. The SPLASH® LIPIDOMIX® Standard includes all of the major lipid classes at ratios relative to human plasma, allowing one easy internal standard solution to be added to every sample. [

Application

15:0-18:1-d7-PI (1-pentadecanoyl-2-oleoyl(d7)-sn-glycero-3-phosphoinositol (ammonium salt)) has been used:
  • as a component of extraction solvent for lipid isolation from biological samples
  • as an internal standard to spike cell lysate and to quantify lipid species using fourier transform mass spectrometry (FTMS) analysis
  • as an isotopically labeled lipid internal standard for correction of lipids detected in lipid droplets using shotgun mass spectrometry analysis

Biochem/physiol Actions

Phosphotidylinositol (PI) undergo phosphorylation in their hydroxyls group and the phosphorylated PIs regulate various biological processes including membrane trafficking, endocytosis and autophagy.

Packaging

2 mL Amber Glass Sealed Ampule (791641C-1mg)

Legal Information

LIPIDOMIX is a registered trademark of Avanti Polar Lipids, Inc.
SPLASH is a registered trademark of Avanti Polar Lipids, Inc.

also commonly purchased with this product

Product No.
Description
Pricing

700041P

cholesterol-d7, Avanti Polar Lipids

791637C

15:0-18:1-d7-PC, Avanti Polar Lipids

791638C

15:0-18:1-d7-PE, Avanti Polar Lipids

791643C

18:1-d7 Lyso PC, Avanti Polar Lipids

791647C

15:0-18:1-d7 DG, Avanti Polar Lipids 791647C

791648C

15:0-18:1-d7-15:0 TG, Avanti Polar Lipids 791648C

791639C

15:0-18:1-d7-PS, Avanti Polar Lipids

791640C

15:0-18:1-d7-PG, Avanti Polar Lipids 791640C

791642C

15:0-18:1-d7-PA, Avanti Polar Lipids

791644C

18:1-d7 Lyso PE, Avanti Polar Lipids 791644C

791645C

18:1-d7-cholesterol, Avanti Polar Lipids 791645C

791646C

18:1-d7 MG, Avanti Polar Lipids 791646C

791649C

18:1-d9 SM, Avanti Polar Lipids

Pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

Signal Word

Danger

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3

Target Organs

Central nervous system

Storage Class Code

6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

WGK

WGK 3

Flash Point(F)

does not flash

Flash Point(C)

does not flash

Regulatory Information

危险化学品
易制毒化学品（2类）

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Robin F Irvine
Journal of lipid research, 57(11), 1987-1994 (2016-11-03)
The diverse family of inositol lipids is now known to be central to many aspects of cell biology. The route from the first discovery of inositol to our present day knowledge of inositol lipids spans more than 150 years and
Nicholas J Blunsom et al.
Biochimica et biophysica acta. Molecular and cell biology of lipids, 1865(1), 158471-158471 (2019-06-08)
Phosphatidylinositol (PI) is a minor phospholipid with a characteristic fatty acid profile; it is highly enriched in stearic acid at the sn-1 position and arachidonic acid at the sn-2 position. PI is phosphorylated into seven specific derivatives, and individual species
Chuchu Wang et al.
Nature communications, 11(1), 1531-1531 (2020-03-27)
Vesicle associated membrane protein 2 (VAMP2/synaptobrevin2), a core SNARE protein residing on synaptic vesicles (SVs), forms helix bundles with syntaxin-1 and SNAP25 for the SNARE assembly. Prior to the SNARE assembly, the structure of VAMP2 is unclear. Here, by using
Florian Geltinger et al.
GeroScience, 42(1), 19-38 (2019-11-05)
Originally Lipid droplets (LDs) were considered as being droplets for lipid storage only. Increasing evidence, however, demonstrates that LDs fulfill a pleiotropy of additional functions. Among them is the modulation of protein as well as lipid homeostasis. Under unfavorable pro-oxidative
Christophe A C Freyre et al.
Molecular cell, 76(5), 811-825 (2019-10-20)
Physical contact between organelles is vital to the function of eukaryotic cells. Lipid droplets (LDs) are dynamic organelles specialized in lipid storage that interact physically with mitochondria in several cell types. The mechanisms coupling these organelles are, however, poorly understood
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