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About This Item
Empirical Formula (Hill Notation):
C42H75D7NO13P
CAS Number:
Molecular Weight:
847.12
MDL number:
UNSPSC Code:
12352211
NACRES:
NA.25
Assay
>99% (TLC)
form
liquid
packaging
pkg of 1 × 1 mL (791641C-1mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand
concentration
1 mg/mL (791641C-1mg)
shipped in
dry ice
storage temp.
−20°C
General description
15:0-18:1-d7-PI (1-pentadecanoyl-2-oleoyl(d7)-sn-glycero-3-phosphoinositol) is a deuterated phospholipid. The lipid comprises the phosphotidylinositol attached to pentadecanoic acid and oleic acid. Oleic acid harbors the deuterium ions. Phosphotidylinositol are esterified inositol associated with bacteria and eukaryotes. It is synthesized in endoplasmic reticulum and is an anionic lipid. The sn-1 and sn-2 positions of the glycerol is esterified with fatty acids. The phosphate group is present in sn-3 position.
This deuterium labeled lipid is also available in a formulation of multiple lipid standards. The SPLASH™ LIPIDOMIX™ Standard includes all of the major lipid classes at ratios relative to human plasma, allowing one easy internal standard solution to be added to every sample. [
Application
15:0-18:1-d7-PI (1-pentadecanoyl-2-oleoyl(d7)-sn-glycero-3-phosphoinositol (ammonium salt)) has been used:
- as a component of extraction solvent for lipid isolation from biological samples
- as an internal standard to spike cell lysate and to quantify lipid species using fourier transform mass spectrometry (FTMS) analysis
- as an isotopically labeled lipid internal standard for correction of lipids detected in lipid droplets using shotgun mass spectrometry analysis
Biochem/physiol Actions
Phosphotidylinositol (PI) undergo phosphorylation in their hydroxyls group and the phosphorylated PIs regulate various biological processes including membrane trafficking, endocytosis and autophagy.
Packaging
2 mL Amber Glass Sealed Ampule (791641C-1mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
LIPIDOMIX is a trademark of Avanti Polar Lipids, LLC
SPLASH is a trademark of Avanti Polar Lipids, LLC
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 Oral - STOT SE 3
Target Organs
Central nervous system, Liver,Kidney
Storage Class Code
6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
WGK
WGK 3
Flash Point(F)
does not flash
Flash Point(C)
does not flash
Regulatory Information
危险化学品
易制毒化学品（2类）
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Robin F Irvine
Journal of lipid research, 57(11), 1987-1994 (2016-11-03)
The diverse family of inositol lipids is now known to be central to many aspects of cell biology. The route from the first discovery of inositol to our present day knowledge of inositol lipids spans more than 150 years and
Nicholas J Blunsom et al.
Biochimica et biophysica acta. Molecular and cell biology of lipids, 1865(1), 158471-158471 (2019-06-08)
Phosphatidylinositol (PI) is a minor phospholipid with a characteristic fatty acid profile; it is highly enriched in stearic acid at the sn-1 position and arachidonic acid at the sn-2 position. PI is phosphorylated into seven specific derivatives, and individual species
Florian Geltinger et al.
GeroScience, 42(1), 19-38 (2019-11-05)
Originally Lipid droplets (LDs) were considered as being droplets for lipid storage only. Increasing evidence, however, demonstrates that LDs fulfill a pleiotropy of additional functions. Among them is the modulation of protein as well as lipid homeostasis. Under unfavorable pro-oxidative
Tong Liu et al.
Expert review of proteomics, 17(3), 233-242 (2020-04-21)
Background: Colorectal cancer (CRC) represents a third leading cause of cancer-related death worldwide. The reliable diagnostic biomarkers for detecting CRC at early stage is critical for decreasing the mortality.Method: A conjunctive lipidomic approach was employed to investigate the differences in
Chuchu Wang et al.
Nature communications, 11(1), 1531-1531 (2020-03-27)
Vesicle associated membrane protein 2 (VAMP2/synaptobrevin2), a core SNARE protein residing on synaptic vesicles (SVs), forms helix bundles with syntaxin-1 and SNAP25 for the SNARE assembly. Prior to the SNARE assembly, the structure of VAMP2 is unclear. Here, by using
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