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About This Item
Empirical Formula (Hill Notation):
C35H62N5O11P
CAS Number:
Molecular Weight:
759.87
UNSPSC Code:
12352211
NACRES:
NA.25
Product Name
14:0-12:0 NBD PA, Avanti Research™ - A Croda Brand 810172C
assay
>99% (TLC)
form
liquid
packaging
pkg of 1 × 1 mL (810172C-1mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand 810172C
concentration
1 mg/mL (810172C-1mg)
shipped in
dry ice
storage temp.
−20°C
General description
Phosphatidic acid (PA) is an anionic membrane phospholipid constituting 1-4% of membrane lipids. It contains a phosphomonoester polar head group and two long hydrophobic acyl chains. NBD PA is a fluorescently labeled lipid with 7-nitrobenz-2-oxa-1,3-diazol-4-yl (NBD) at the sn-2 fatty acid of PA.
Biochem/physiol Actions
Phosphatidic acid (PA) plays a vital role as a signaling molecule in the regulation of cellular processes including cell proliferation, survival, cytoskeletal organization, vesicular trafficking, secretion and reproduction. It acts as a parent compound to generate other phospholipids.
Packaging
5 mL Amber Glass Screw Cap Vial (810172C-1mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
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signalword
Danger
Hazard Classifications
Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3
target_organs
Central nervous system
Storage Class
6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
wgk
WGK 3
flash_point_f
does not flash
flash_point_c
does not flash
Regulatory Information
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Mikhail A Zhukovsky et al.
FEBS letters, 593(17), 2428-2451 (2019-08-01)
Phosphatidic acid (PA) is the simplest cellular glycerophospholipid characterized by unique biophysical properties: a small headgroup; negative charge; and a phosphomonoester group. Upon interaction with lysine or arginine, PA charge increases from -1 to -2 and this change stabilizes protein-lipid
Phosphatidic acid in membrane rearrangements
Zhukovsky MA, et al.
Febs Letters, 593(17), 2428-2451 (2019)
A Chauhan et al.
Neurochemical research, 25(3), 423-429 (2000-04-13)
Fibrillar amyloid beta-protein (Abeta) is the major protein of amyloid plaques in the brains of patients with Alzheimer's disease (AD). The mechanism by which normally produced soluble Abeta gets fibrillized in AD is not clear. We studied the effect of
Global Trade Item Number
| SKU | GTIN |
|---|---|
| 810172C-1MG | 04061837666629 |