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About This Item
Empirical Formula (Hill Notation):
C39H68N5O11P
CAS Number:
Molecular Weight:
813.96
MDL number:
UNSPSC Code:
12352211
NACRES:
NA.25
Product Name
18:1-12:0 NBD PA, Avanti Research™ - A Croda Brand 810176C
Assay
>99% (TLC)
form
liquid
packaging
pkg of 1 × 1 mL (810176C-1mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand 810176C
concentration
1 mg/mL (810176C-1mg)
shipped in
dry ice
storage temp.
−20°C
General description
Phosphatidic acid (PA) is a simple anionic membrane phospholipid. The amphipathic phospholipid contains a polar head group and two long hydrophobic acyl chains. NBD PA is a fluorescent probe containing 7-nitrobenz-2-oxa-1,3-diazol-4-yl (NBD) linked to the sn-2 fatty acid of PA.
Application
18:1-12:0 NBD PA or 1-oleoyl-2-{12-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]dodecanoyl}-sn-glycero-3-phosphate (ammonium salt) has been used in donor liposomes for phosphatidic acid (PA) transfer activity assay. It might be used:in the preparation of PA small unilamellar vesicles (SUVs) to determine mammalian target of rapamycin complex 1 (mTORC1) lysosomal translocation. It may be used in NBD-PA and NBD phosphatidyl choline uptake assays and to measure lipid transfer specificity of Ups1 mutants
Biochem/physiol Actions
Phosphatidic acid (PA) is crucial for intracellular signaling involved in various cellular processes, including membrane trafficking and sperm hyper-activation. PA reacts with water and other phospholipids to produce lipid bilayers and multicomponent bilayers, respectively.
Packaging
5 mL Amber Glass Screw Cap Vial (810176C-1mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3
Target Organs
Central nervous system, Liver,Kidney
WGK
WGK 3
Regulatory Information
易制毒化学品（2类）
危险化学品
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Structural determinants of lipid specificity within Ups/PRELI lipid transfer proteins
Miliara X, et al.
Nature Communications null
Phosphatidic acid drives mTORC1 lysosomal translocation in the absence of amino acids
Frias MA, et al.
Test null
Aster-B coordinates with Arf1 to regulate mitochondrial cholesterol transport
Andersen JP, et al.
Molecular Metabolism null
Molecular mechanism of mitochondrial phosphatidate transfer by Ups1
Lu J, et al.
Communications biology null
Bioactive Lipids
An Introduction to Biological Membranes, 453-478 (2016)
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