Skip to Content
Merck
CN

810233C

Avanti

C12-NBD L-threo-Sphingosine

Avanti Research™ - A Croda Brand

Synonym(s):

N-[12-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]dodecanoyl]-L-threo-sphingosine

Sign Into View Organizational & Contract Pricing

Select a Size

About This Item

Empirical Formula (Hill Notation):
C36H61N5O6
CAS Number:
474943-08-3
Molecular Weight:
659.90
UNSPSC Code:
12352211
NACRES:
NA.25

Key Documents

View All Documentation
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

Product Name

C12-NBD L-threo-Sphingosine, Avanti Research™ - A Croda Brand 810233C

Assay

>99% (TLC)

form

liquid

packaging

pkg of 1 × 1 mL (810233C-50ug)

manufacturer/tradename

Avanti Research™ - A Croda Brand 810233C

concentration

0.05 mg/mL (810233C-50ug)

shipped in

dry ice

storage temp.

−20°C

General description

C12-NBD L-threo-Sphingosine is an analog of L-threo-sphingosine with a fluorescent NBD group. Sphingosine is an amino alcohol that belongs to the class of sphingolipids. L-threo-Sphingosine is one of the four isomers of sphingosine, which can be differentiated by CD spectroscopy.

Biochem/physiol Actions

Sphingosine is uniquely produced by de-acylation of ceramide. It can be converted back to ceramide by the scavenger pathway. Several studies suggest that sphingosine functions as a tumor-suppressor lipid that mediates growth arrest, senescence, apoptosis and differentiation. Treatment of cells with sphingosine is known to inhibit the activity of the mitogen activated protein kinases (MAPKs), extracellular signal-regulated kinases (Erk-1 and Erk-2), and activate stress-activated protein kinases (SAPKs) such as Jun amino-terminal kinases (JNK) and p38.

Packaging

5 mL Amber Glass Screw Cap Vial (810233C-50ug)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

Signal Word

Danger

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3

Target Organs

Central nervous system

Storage Class Code

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

WGK

WGK 3

Flash Point(F)

does not flash

Flash Point(C)

does not flash

Regulatory Information

新产品
This item has

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

It looks like we've run into a problem, but you can still download Certificates of Analysis from our Documents section.

If you need assistance, please contact Customer Support

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Sodium, 58(8), 462-466 (2016)
Joanna Woodcock
IUBMB life, 58(8), 462-466 (2006-08-19)
The sphingomyelin pathway is activated in response to many apoptotic stimuli leading to the accumulation of breakdown products ceramide and sphingosine. Ceramide has received much attention as an apoptotic second messenger whereas sphingosine has largely been overlooked as a mediator
Padmavathi Bandhuvula et al.
Journal of lipid research, 48(12), 2769-2778 (2007-09-18)
Sphingosine-1-phosphate (S1P) lyase (SPL) catalyzes the conversion of S1P to ethanolamine phosphate and hexadecenal. This enzyme plays diverse roles in physiology and disease and, thus, may be useful as a disease marker and/or drug target. Unfortunately, the radioisotope-based assay currently
Raghavendra Pralhada Rao et al.
Journal of lipids, 2013, 178910-178910 (2013-08-29)
Sphingolipids, a family of membrane lipids, are bioactive molecules that participate in diverse functions controlling fundamental cellular processes such as cell division, differentiation, and cell death. Given that most of these cellular processes form the basis for several pathologies, it
Medical Applications of Mass Spectrometry (2008)
View All Related Papers

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service