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Merck
CN

850320P

Avanti

09:0 PC

Avanti Research™ - A Croda Brand

Synonym(s):

PC(9:0/9:0)

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About This Item

Empirical Formula (Hill Notation):
C26H52NO8P
CAS Number:
27869-45-0
Molecular Weight:
537.67
MDL number:
MFCD00082437
UNSPSC Code:
51191904
NACRES:
NA.25

Key Documents

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Product Name

09:0 PC, 1,2-dinonanoyl-sn-glycero-3-phosphocholine, powder

SMILES string

[O-]P(OCC[N+](C)(C)C)(OC[C@]([H])(OC(CCCCCCCC)=O)COC(CCCCCCCC)=O)=O

InChI

1S/C26H52NO8P/c1-6-8-10-12-14-16-18-25(28)32-22-24(35-26(29)19-17-15-13-11-9-7-2)23-34-36(30,31)33-21-20-27(3,4)5/h24H,6-23H2,1-5H3/t24-/m1/s1

InChI key

CKGVBFQDYSPMSY-XMMPIXPASA-N

assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 25 mg (850320P-25mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand 850320P

lipid type

cardiolipins
phospholipids

shipped in

dry ice

storage temp.

−20°C

Application

09:0 PC (1,2-dinonanoyl-sn-glycero-3-phosphocholine) may be used:
  • as an internal standard for phospholipid extraction from renal tissues using liquid chromatography coupled to electrospray ionization tandem mass spectrometry
  • as a supplement in sample mixture as internal standard for liquid-liquid extraction and to spike the samples in order to determine lipid extract from fibroblasts by high-performance liquid chromatography/electrospray ionization tandem mass spectrometry (HPLC/ESI-MS/MS)
  • an internal standard to spike frozen aliquots of plas ma in liquid chromatography with tandem mass spectrometry (LC-MS-MS)

Biochem/physiol Actions

Phosphatidylcholine (PC) may participate in the signaling of neuronal differentiation.

General description

Phosphatidylcholines (PCs) are amphipathic molecules, which accounts for approximately 40−50% of the total cellular phospholipids. PCs are mainly located on the outer leaflets of the biological membrane bilayer.
The list of Phosphatidylcholine products offered by Avanti is designed to provide compounds having a variety of physical properties. Products available include short chain (C3-C8 are water soluble and hygroscopic), saturated, multi-unsaturated and mixed acid PC′s. All of the products are purified by HPLC, and special precautions are taken to protect the products for oxidization and hydrolysis.

Packaging

5 mL Clear Glass Sealed Ampule (850320P-25mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Storage Class

10 - Combustible liquids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Maria Philippova et al.
Free radical biology & medicine, 144, 167-175 (2019-05-30)
Circulating oxidized phospholipids are increasingly recognized as biomarkers of atherosclerosis. Clinical association studies have been mainly performed using an immune assay based on monoclonal antibody E06, which recognizes a variety of molecular species of oxidized phosphatidylcholine (OxPC) in lipoproteins, cell
Florian Gruber et al.
Journal of lipid research, 53(6), 1232-1242 (2012-03-15)
Oxidized phospholipids (OxPLs) are increasingly recognized as signaling mediators that are not only markers of oxidative stress but are also "makers" of pathology relevant to disease pathogenesis. Understanding the biological role of individual molecular species of OxPLs requires the knowledge
Zahra Solati et al.
PloS one, 13(4), e0195172-e0195172 (2018-04-24)
The aim of this study was to determine the individual oxidized phosphatidylcholine (OxPC) molecules generated during renal ischemia/ reperfusion (I/R) injury. Kidney ischemia was induced in male Sprague-Dawley rats by clamping the left renal pedicle for 45 min followed by
Luciana Paoletti et al.
IUBMB life, 63(9), 714-720 (2011-08-06)
Neuronal differentiation is characterized by neuritogenesis and neurite outgrowth, processes, which are critically dependent on membrane biosynthesis, and therefore, on the expression and regulation of enzymes involved in phospholipid biosynthesis. During the last decade a great effort was made to
Jelske N van der Veen et al.
Biochimica et biophysica acta. Biomembranes, 1859(9 Pt B), 1558-1572 (2017-04-16)
Phosphatidylcholine (PC) and phosphatidylethanolamine (PE) are the most abundant phospholipids in all mammalian cell membranes. In the 1950s, Eugene Kennedy and co-workers performed groundbreaking research that established the general outline of many of the pathways of phospholipid biosynthesis. In recent

Articles

Critical Micelle Concentrations (CMCs) - Avanti Research™ Polar Lipids

The critical micelle concentration (CMC) can be approximately defined as the lipid monomer concentration at which appreciable amounts (>5% of total) of micellar aggregates first begin to appear in the equilibrium: nM1<=>Mn

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