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About This Item
Empirical Formula (Hill Notation):
C19H42NO4P
CAS Number:
Molecular Weight:
379.51
MDL number:
UNSPSC Code:
12352211
NACRES:
NA.25
Product Name
MAPCHO™-14, n-tetradecylphosphocholine, powder
Assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 1 g (850338P-1g)
pkg of 1 × 10 g (850338P-10g)
manufacturer/tradename
Avanti Research™ - A Croda Brand 850338P
shipped in
dry ice
storage temp.
−20°C
SMILES string
[P](=O)([O-])(OCC[N+](C)(C)C)OCCCCCCCCCCCCCC
InChI
1S/C19H42NO4P/c1-5-6-7-8-9-10-11-12-13-14-15-16-18-23-25(21,22)24-19-17-20(2,3)4/h5-19H2,1-4H3
InChI key
BETUMLXGYDBOLV-UHFFFAOYSA-N
General description
MAPCHO™-14 is a fos-choline-based zwitterionic detergent.
Tetradecylphosphocholine is a structural analog of myristoyl lysophosphatidylcholine that is more stable to hydrolytic degradation. The lipid is often used as a detergent for membrane protein solubilization and purification. It has been used as a helper lipid for in vitro and in vivo gene transfer, and it has been shown to have some anticancer activity.
Application
MAPCHO™-14 has been used as a supplement in extraction buffer (RIPA buffer).
Biochem/physiol Actions
Fos-choline-14 (N-tetradecylphosphocholine) is mainly used for solubilization and purification of proteins.
Packaging
20 mL Clear Glass Screw Cap Vial (850338P-1g)
60 mL Amber Wide Mouth Screw Cap Glass Bottle (850338P-10g)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
MAPCHO is a trademark of Avanti Polar Lipids, LLC
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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Brian L Cook et al.
PloS one, 3(8), e2920-e2920 (2008-08-07)
In order to begin to study the structural and functional mechanisms of olfactory receptors, methods for milligram-scale purification are required. Here we demonstrate the production and expression of a synthetically engineered human olfactory receptor hOR17-4 gene in a stable tetracycline-inducible
Study of a synthetic human olfactory receptor 17-4: expression and purification from an inducible mammalian cell line
Cook BL, et al.
Testing, 3(8), e2920-e2920 (2008)
Impaired endothelial barrier function in apolipoprotein M-deficient mice is dependent on sphingosine-1-phosphate receptor 1
Christensen PM, et al.
Faseb Journal, 30(6), 2351-2359 (2016)
Pernille M Christensen et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 30(6), 2351-2359 (2016-03-10)
Apolipoprotein M (ApoM) transports sphingosine-1-phosphate (S1P) in plasma, and ApoM-deficient mice (Apom(-/-)) have ∼50% reduced plasma S1P levels. There are 5 known S1P receptors, and S1P induces adherens junction formation between endothelial cells through the S1P1 receptor, which in turn
Christoph Göbl et al.
The journal of physical chemistry. B, 114(13), 4717-4724 (2010-03-17)
The interaction with biological membranes is of functional importance for many peptides and proteins. Structural studies on such membrane-bound biomacromolecules are often carried out in solutions containing small membrane-mimetic assemblies of detergent molecules. To investigate the influence of the hydrophobic
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