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850458C

Avanti

16:0-18:2 PC

Avanti Polar Lipids

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Synonym(s):
1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine; PC(16:0/18:2(9Z,12Z))
Empirical Formula (Hill Notation):
C42H80NO8P
CAS Number:
159701-21-0
Molecular Weight:
758.06
NACRES:
NA.25

description

1-palmitoyl-2-linoleoyl-sn-glycero-3-phosphocholine, chloroform

Assay

>99% (TLC)

form

liquid

packaging

pkg of 1 × 2.5 mL (850458C-25mg)
pkg of 2 × 4 mL (850458C-200mg)

manufacturer/tradename

Avanti Polar Lipids

concentration

10 mg/mL (850458C-25mg)
25 mg/mL (850458C-200mg)

lipid type

cardiolipins
phospholipids

shipped in

dry ice

storage temp.

−20°C

SMILES string

[O-]P(OCC[N+](C)(C)C)(OC[C@]([H])(OC(CCCCCCC/C=C\C/C=C\CCCCC)=O)COC(CCCCCCCCCCCCCCC)=O)=O

General description

16:0-18:2 PC or 1-palmitoyl-2-linoleoyl-sn-glycero-3-phosphocholine is a glycerophospholipid, with substitution of palmitic acid and linolenic acid at sn-1 and sn-2 positions of the glycerol backbone, respectively.

Application

16:0-18:2 PC or 1-palmitoyl-2-linoleoyl-sn-glycero-3-phosphocholine might be used to study the effects of phosphatidylcholines (PCs) on lubrication of damaged mesothelium. It has also been used to prepare liposomes with Hong Jing Tian (HJT)-small RNA-m7, in an attempt to show small plant RNA entry into human cells and the mouse lung, in vitro and in vivo.

Packaging

5 mL Clear Glass Sealed Ampule (850458C-200mg)
5 mL Clear Glass Sealed Ampule (850458C-25mg)

Pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

Signal Word

Danger

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 Oral - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

WGK

WGK 3

Regulatory Information

易制毒化学品（2类）
危险化学品

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Giulia Coliva et al.
Molecules (Basel, Switzerland), 25(8) (2020-04-25)
Free radical driven lipid peroxidation is a chain reaction which can lead to oxidative degradation of biological membranes. Propagation vs. termination rates of peroxidation in biological membranes are determined by a variety of factors including fatty acyl chain composition, presence
Jianchao Du et al.
Science China. Life sciences, 62(3), 309-320 (2017-04-06)
Pulmonary fibrosis, a progressive chronic disease with a high mortality rate, has limited treatment options. Currently, lung transplantation remains the only effective treatment. Here we report that a small RNA, HJT-sRNA-m7, from a Chinese herbal medicine Hong Jing Tian (HJT
John K Eaton et al.
Nature chemical biology, 16(5), 497-506 (2020-04-02)
We recently described glutathione peroxidase 4 (GPX4) as a promising target for killing therapy-resistant cancer cells via ferroptosis. The onset of therapy resistance by multiple types of treatment results in a stable cell state marked by high levels of polyunsaturated
Francesca Bodega et al.
Respiratory physiology & neurobiology, 203, 116-120 (2014-08-17)
Effect of time and phosphatidylcholines (PCs) on lubrication of damaged mesothelium has been investigated. Marked increase in coefficient of kinetic friction (μ) of pleural specimens after mesothelial blotting and rewetting decreased by 23.4±3.5%, 41.8±3.8%, and 40.5±2.7% after 30min, 1h, and
Eikan Mishima et al.
Journal of the American Society of Nephrology : JASN, 31(2), 280-296 (2019-11-27)
Ferroptosis, nonapoptotic cell death mediated by free radical reactions and driven by the oxidative degradation of lipids, is a therapeutic target because of its role in organ damage, including AKI. Ferroptosis-causing radicals that are targeted by ferroptosis suppressors have not
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