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About This Item
Empirical Formula (Hill Notation):
C19H36O4
CAS Number:
Molecular Weight:
328.49
MDL number:
UNSPSC Code:
12352211
NACRES:
NA.25
Product Name
7.9 MAG, Avanti Research™ - A Croda Brand 850534O
InChI
1S/C19H36O4/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-19(22)23-17-18(21)16-20/h9-10,18,20-21H,2-8,11-17H2,1H3/b10-9-
InChI key
OWGMAJRKMYGYBQ-KTKRTIGZSA-N
SMILES string
OCC(O)COC(CCCCC/C=C\CCCCCCCC)=O
assay
>99% (TLC)
form
oil
mol wt
328.49 g/mol
packaging
pkg of 2 × 100 mg (with screw cap (850534O-200mg))
manufacturer/tradename
Avanti Research™ - A Croda Brand 850534O
technique(s)
protein sequencing: suitable
shipped in
dry ice
storage temp.
−20°C
Application
7.9 MAG is suitable for use as a hosting lipid for titration to avoid lamellar crystal phase (Lc) formation during sample injection It is also suitable for use in mesocrystallization.
Biochem/physiol Actions
7.9 MAG is a non-monoolein lipid. It can support crystallization of bacteriorhodopsin, an integral membrane protein.
General description
This new Lipid detergent may be used for crystallizing membrane proteins by using lipidic mesophases. This method has variously been referred to as the lipidic cubic phase or in meso method. The method has been shown to be quite versatile in that it has been used to solve X-ray crystallographic structures of prokaryotic and eukaryotic proteins, proteins that are monomeric, homo- and hetero-multimeric, chromophore-containing and chromophore-free, and alpha-helical and beta-barrel proteins.
Packaging
5 mL PTFE Vial with Screw Cap (850534O-200mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
Storage Class
11 - Combustible Solids
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In Meso Crystallization of the Integral Membrane Glycerol 3-Phosphate Acyltransferase with Substrates
Li Z, et al.
Crystal Growth & Design, 18(4), 2243-2258 (2018)
Membrane protein crystallization in lipidic mesophases with tailored bilayers
Misquitta LV, et al.
Structure, 12(12), 2113-2124 (2004)
Preparation and delivery of protein microcrystals in lipidic cubic phase for serial femtosecond crystallography
Ishchenko A, et al.
Journal of Visualized Experiments, (115), e54463-e54463 (2016)
Niklaus Johner et al.
Journal of the American Chemical Society, 136(8), 3271-3284 (2014-02-06)
The recent advances in the in meso crystallization technique for the structural characterization of G-protein coupled receptor (GPCR) proteins have established the usefulness of the lipidic-cubic phases (LCPs) in the field of crystallography of membrane proteins. It is surprising that
Martin Caffrey et al.
Journal of visualized experiments : JoVE, (45) (2010-11-30)
A detailed protocol for crystallizing membrane proteins by using lipidic mesophases is described. This method has variously been referred to as the lipidic cubic phase or in meso method. The method has been shown to be quite versatile in that
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