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860389P

Avanti

26:0-d4 Lyso PC

1-hexacosanoyl-d4-2-hydroxy-sn-glycero-3-phosphocholine, powder

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Synonym(s):
1-hexacosanoyl(12,12,13,13-D4)-sn-glycero-3-phosphocholine
Empirical Formula (Hill Notation):
C34H66D4NO7P
CAS Number:
1246303-15-0
Molecular Weight:
639.92
NACRES:
NA.25

Assay

>99% (LPC; may contain up to 10% of the 2-LPC isomer, TLC)

form

powder

packaging

pkg of 1 × 1 mg (860389P-1mg)
pkg of 1 × 5 mg (860389P-5mg)

manufacturer/tradename

Avanti Polar Lipids 860389P

shipped in

dry ice

storage temp.

−20°C

General description

26:0-d4 Lyso PC is a deuterated lysophosphatidylcholine (lyso pc) in which 4 protons of hexacosanoyl are replaced by deuterium.

Application

26:0-d4 Lyso PC has been used as an internal standard to extract total very long chain fatty acids (VLCFAs) from brain, testes and adrenal glands.

Packaging

5 mL Amber Glass Screw Cap Vial (860389P-1mg)
5 mL Amber Glass Screw Cap Vial (860389P-5mg)

Storage Class Code

11 - Combustible Solids

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Walter C Hubbard et al.
Molecular genetics and metabolism, 97(3), 212-220 (2009-05-09)
Newborn screening for X-linked adrenoleukodystrophy (X-ALD) has until now been limited in implementation because of the lack of an accepted standard methodology. We have previously reported a technique using LC-MS/MS analysis that could provide the basis for screening of newborns
Wedad Fallatah et al.
Disease models & mechanisms, 13(1) (2019-12-22)
Rhizomelic chondrodysplasia punctata (RCDP) is a rare genetic disorder caused by mutations in peroxisomal genes essential for plasmalogen biosynthesis. Plasmalogens are a class of membrane glycerophospholipids containing a vinyl-ether-linked fatty alcohol at the sn-1 position that affect functions including vesicular
A thyroid hormone-based strategy for correcting the biochemical abnormality in X-linked adrenoleukodystrophy
Hartley MD, et al.
Endocrinology, 158(5), 1328-1338 (2017)
John Williams et al.
Bioanalysis, 12(3), 143-158 (2020-02-14)
Aim: Very long chain fatty acids (VLCFAs) have been identified as biomarkers for several peroxisomal disorders necessitating the need for reliable biomarker assays in particular C20, C22, C24, C26 in cerebrospinal fluid (CSF). Until now no absolute quantitation assay for

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