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Merck
CN

860581C

Avanti

18:1-12:0 Biotin PG

Avanti Research™ - A Croda Brand

Synonym(s):

1-oleoyl-2-[12-biotinyl(aminododecanoyl)]-sn-glycero-3-phospho-(1′-rac-glycerol) (sodium salt)

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About This Item

Empirical Formula (Hill Notation):
C46H83 N3NaO12PS
Molecular Weight:
956.19
UNSPSC Code:
12352211
NACRES:
NA.25

Key Documents

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form

liquid

packaging

pkg of 1 × 1 mL (860581C-10mg)
pkg of 1 × 1 mL (860581C-1mg)
pkg of 1 × 1 mL (860581C-5mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand

concentration

1 mg/mL (860581C-1mg)
10 mg/mL (860581C-10mg)
5 mg/mL (860581C-5mg)

shipped in

dry ice

storage temp.

−20°C

SMILES string

[H][C@@](COP([O-])(OCC(O)CO)=O)(OC(CCCCCCCCCCCNC(CCCC[C@]1([H])SC[C@@]2([H])[C@]1([H])NC(N2)=O)=O)=O)COC(CCCCCCC/C=C\CCCCCCCC)=O.[Na+]

Application

18:1-12:0 Biotin PG or 1-oleoyl-2-[12-biotinyl(aminododecanoyl)]-sn-glycero-3-phospho-(1′-rac-glycerol) (sodium salt) has been used in lipid blot analysis to study Niemann-Pick C2 (NPC2)-lipid interactions.

Packaging

5 mL Clear Glass Sealed Ampule (860581C-10mg)
5 mL Clear Glass Sealed Ampule (860581C-1mg)
5 mL Clear Glass Sealed Ampule (860581C-5mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

Signal Word

Danger

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3

Target Organs

Central nervous system

Storage Class Code

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

WGK

WGK 3

Flash Point(F)

does not flash

Flash Point(C)

does not flash

Regulatory Information

易制毒化学品（2类）
危险化学品
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Leslie A McCauliff et al.
eLife, 8 (2019-10-04)
Unesterified cholesterol accumulation in the late endosomal/lysosomal (LE/LY) compartment is the cellular hallmark of Niemann-Pick C (NPC) disease, caused by defects in the genes encoding NPC1 or NPC2. We previously reported the dramatic stimulation of NPC2 cholesterol transport rates to

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