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Merck
CN

870608H

Avanti

4-HNE-dimethylacetal

Avanti Research™ - A Croda Brand

Synonym(s):

(E)-4R-hydroxynonenal-dimethylacetal (Each vial contains 6.8mg which yields ~5.2mg 4-HNE after deprotection)

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About This Item

Empirical Formula (Hill Notation):
C11H22O3
CAS Number:
119009-01-7
Molecular Weight:
202.29
MDL number:
MFCD22416914
UNSPSC Code:
12352211
NACRES:
NA.25

Key Documents

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Product Name

4-HNE-dimethylacetal, Avanti Research™ - A Croda Brand 870608H, hexane solution

InChI key

ATGIHMSJAARJTF-AAXQSMANSA-N

SMILES string

CCCCC[C@@H](O)/C=C/C(OC)OC

assay

>99% (TLC)

form

hexane solution

packaging

pkg of 1 × 1 mL (870608H-5mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand 870608H

concentration

6.8 mg/mL (870608H-5mg)

lipid type

phosphoglycerides
bioactive lipids

shipped in

dry ice

storage temp.

−20°C

General description

4-Hydroxynonenal (4-HNE or HNE) is an α,β-unsaturated hydroxyalkenal which is produced by lipid peroxidation in cells. 4-HNE has been hypothesized by several researchers to play a key role in cell signal transduction, in a variety of pathways from cell cycle events to cellular adhesion.
The dimethylacetal derivative is a more stable form of 4-HNE which is good for long term storage of the compound during use. It can be easily converted to 4-HNE in the presence of acid.

Packaging

2 mL Amber Glass Sealed Ampule (870608H-5mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Disclaimer

Supply conditions do not apply to the regions and states of Brazil: North, Northeast, Mato Grosso do Sul, Mato Grosso, and Rio Grande do Sul.

signalword

Danger

Hazard Classifications

Aquatic Chronic 2 - Asp. Tox. 1 - Flam. Liq. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 Inhalation - STOT SE 3

target_organs

Central nervous system, Nervous system

Storage Class

3 - Flammable liquids

wgk

WGK 3

flash_point_f

-14.8 °F - closed cup

flash_point_c

-26.0 °C - closed cup

Regulatory Information

危险化学品
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N Zarković et al.
Life sciences, 65(18-19), 1901-1904 (1999-11-27)
Immunohistochemical analysis of the distribution of the lipid peroxidation product 4-hydroxynonenal (HNE) in the brain of baboons exposed to experimental hemorrhagic traumatic shock or sepsis showed that systemic oxidative stress and the thereby generated HNE affect the blood:brain barrier and
Neven Zarkovic
Molecular aspects of medicine, 24(4-5), 281-291 (2003-08-02)
The review is focused on the currently major aspect of 4-hydroxynonenal (HNE) research--studies that combine biological activities of the aldehyde together with the methods of its identification in cells and tissues. Because there were some excellent reviews on HNE published
Yogesh C Awasthi et al.
Free radical biology & medicine, 37(5), 607-619 (2004-08-04)
4-Hydroxynonenal (HNE), one of the major end products of lipid peroxidation, has been shown to be involved in signal transduction and available evidence suggests that it can affect cell cycle events in a concentration-dependent manner. Glutathione S-transferases (GSTs) can modulate
Rajendra Sharma et al.
European journal of biochemistry, 271(9), 1690-1701 (2004-04-21)
4-Hydroxy-2-trans-nonenal (4-HNE), one of the major end products of lipid peroxidation, has been shown to induce apoptosis in a variety of cell lines. It appears to modulate signaling processes in more than one way because it has been suggested to
On the role of 4-hydroxynonenal in health and disease
Csala M, et al.
Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease, 1852(5), 826-838 (2015)
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