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About This Item
Empirical Formula (Hill Notation):
C36H73N10O17P3S
CAS Number:
Molecular Weight:
1043.01
MDL number:
UNSPSC Code:
12352211
NACRES:
NA.25
Product Name
15:0 Coenzyme A, Avanti Research™ - A Croda Brand 870715P, powder
Assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 5 mg (870715P-5mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand 870715P
application(s)
lipidomics
lipid type
coenzymes
shipped in
dry ice
storage temp.
−20°C
SMILES string
O[C@@](C(NCCC(NCCSC(CCCCCCCCCCCCCC)=O)=O)=O)(C(C)(COP([O-])(OP([O-])(OC[C@H]([C@H]1OP([O-])(O)=O)O[C@H]([C@@H]1O)N2C3=C(C(N)=NC=N3)N=C2)=O)=O)C)[H].[NH4+].[NH4+].[NH4+]
General description
15:0 Coenzyme A, also known as pentadecanoyl Coenzyme A, is a coenzyme A derivative of pentadecanoic acid. 15:0 Coenzyme A is a long-chain acyl CoA and the product of the first round of β-oxidation. It is a substrate for serine palmitoyltransferase (SPT) for de novo synthesis of C17-long chain bases.
Application
15:0 Coenzyme A has been used as a constituent of reaction cocktail in microsomal serine palmitoyltransferase (SPT) assay.
Packaging
5 mL Amber Glass Screw Cap Vial (870715P-5mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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Use of isotopically labeled substrates reveals kinetic differences between human and bacterial serine palmitoyltransferase
Harrison PJ, et al.
Journal of Lipid Research, 60(5), 953-962 (2019)
Peter J Harrison et al.
Journal of lipid research, 60(5), 953-962 (2019-02-23)
Isotope labels are frequently used tools to track metabolites through complex biochemical pathways and to discern the mechanisms of enzyme-catalyzed reactions. Isotopically labeled l-serine is often used to monitor the activity of the first enzyme in sphingolipid biosynthesis, serine palmitoyltransferase
Analysis of coenzyme A activated compounds in actinomycetes
Cabruja M, et al.
Applied Microbiology and Biotechnology, 100(16), 7239-7248 (2016)
Matías Cabruja et al.
Applied microbiology and biotechnology, 100(16), 7239-7248 (2016-06-09)
Acyl-CoAs are crucial compounds involved in essential metabolic pathways such as the Krebs cycle and lipid, carbohydrate, and amino acid metabolisms, and they are also key signal molecules involved in the transcriptional regulation of lipid biosynthesis in many organisms. In
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