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870726P

Avanti

26:0 Coenzyme A

Name: 26:0 Coenzyme A
Brand: AVANTI

Avanti Polar Lipids 870726P, powder

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Synonym(s):

hexacosanoyl Coenzyme A (ammonium salt)

Empirical Formula (Hill Notation):

C₄₇H₉₅N₁₀O₁₇P₃S

CAS Number:

799813-02-8

Molecular Weight:

1197.30

form

powder

packaging

pkg of 1 × 10 mg (870726P-10mg)
pkg of 1 × 5 mg (870726P-5mg)

manufacturer/tradename

Avanti Polar Lipids 870726P

application(s)

lipidomics

lipid type

coenzymes

shipped in

dry ice

storage temp.

−20°C

SMILES string

O[C@@](C(NCCC(NCCSC(CCCCCCCCCCCCCCCCCCCCCCCCC)=O)=O)=O)(C(C)(COP([O-])(OP([O-])(OC[C@H]([C@H]1OP([O-])(O)=O)O[C@H]([C@@H]1O)N2C3=C(C(N)=NC=N3)N=C2)=O)=O)C)[H].[NH4+].[NH4+].[NH4+]

InChI

1S/C47H86N7O17P3S.3H3N/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-26-27-38(56)75-31-30-49-37(55)28-29-50-45(59)42(58)47(2,3)33-68-74(65,66)71-73(63,64)67-32-36-41(70-72(60,61)62)40(57)46(69-36)54-35-53-39-43(48)51-34-52-44(39)54;;;/h34-36,40-42,46,57-58H,4-33H2,1-3H3,(H,49,55)(H,50,59)(H,63,64)(H,65,66)(H2,48,51,52)(H2,60,61,62);3*1H3/t36-,40?,41+,42+,46-;;;/m1.../s1

InChI key

XKPNJROJQZVENY-PQBGVFARSA-N

General description

26:0 Coenzyme A , also known as hexacosanoyl Coenzyme A, is a coenzyme derivative of hexacosanoic acid. It is found in high concentration in ATP binding cassette transporter D1-deficient cells.

Application

26:0 Coenzyme A has been used as a substrate for microsomal enzyme 1-acylglycerol-3-phosphate-O-acyltransferase 11 (AGPAT11).

Packaging

5 mL Amber Glass Screw Cap Vial (870726P-10mg)

5 mL Amber Glass Screw Cap Vial (870726P-5mg)

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

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Encephalopathy caused by ablation of very long acyl chain ceramide synthesis may be largely due to reduced galactosylceramide levels.

Oshrit Ben-David et al.

The Journal of biological chemistry, 286(34), 30022-30033 (2011-06-28)

Sphingolipids (SLs) act as signaling molecules and as structural components in both neuronal cells and myelin. We now characterize the biochemical, histological, and behavioral abnormalities in the brain of a mouse lacking very long acyl (C22-C24) chain SLs. This mouse

Enzymatic activity of the human 1-acylglycerol-3-phosphate-O-acyltransferase isoform 11: upregulated in breast and cervical cancers.

Anil K Agarwal et al.

Journal of lipid research, 51(8), 2143-2152 (2010-04-07)

The conversion of lysophosphatidic acid (LPA) to phosphatidic acid is carried out by the microsomal enzymes 1-acylglycerol-3-phosphate-O-acyltransferases (AGPATs). These enzymes are specific for acylating LPA at the sn-2 (carbon 2) position on the glycerol backbone and are important, because they

Hexacosenoyl-CoA is the most abundant very long-chain acyl-CoA in ATP binding cassette transporter D1-deficient cells.

Kotaro Hama et al.

Journal of lipid research, 61(4), 523-536 (2020-02-23)

X-linked adrenoleukodystrophy (X-ALD) is an inherited disorder caused by deleterious mutations in the ABCD1 gene. The ABCD1 protein transports very long-chain FAs (VLCFAs) from the cytosol into the peroxisome where the VLCFAs are degraded through β-oxidation. ABCD1 dysfunction leads to

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