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Merck
CN

880121C

Avanti

DSPE-PEG(2000) Succinyl

Avanti Research - A Croda Brand

Synonym(s):

1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[succinyl(polyethylene glycol)-2000] (ammonium salt)

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About This Item

CAS Number:
UNSPSC Code:
12352211
NACRES:
NA.25
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Product Name

DSPE-PEG(2000) Succinyl, Avanti Research - A Croda Brand 880121C

Assay

>99% (TLC)

form

liquid

packaging

pkg of 1 × 1 mL (880121C-10mg)

manufacturer/tradename

Avanti Research - A Croda Brand 880121C

concentration

10 mg/mL (880121C-10mg)

shipped in

dry ice

storage temp.

−20°C

SMILES string

[H][C@@](COP([O-])(OCCNC(OCCOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO/C=C\N([H])C(CCC(O)=O)=O)=O)=O)(OC(CCCCCCCCCCCCCCCCC)=O)COC(CCCCCCCCCCCCCCCCC)=O.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=

General description

DSPE-PEG(2000) Succinyl is widely used in liposome preparation.
DSPE-PEG(2000) Succinyl or 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[succinyl(polyethylene glycol)-2000] is a functionalized PEG lipid.

Application

DSPE-PEG(2000) Succinyl has been used in micelle synthesis.
DSPE-PEG(2000) succinyl has been used to prepare PEGylated liposomes, to obtain sterically stabilized liposomes containing docetaxel. It has also been used in liposomes for vasoactive intestinal peptide (VIP) encapsulation, to achieve PEGylation.

Packaging

5 mL Clear Glass Sealed Ampule (880121C-10mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Pictograms

Skull and crossbonesHealth hazard

Signal Word

Danger

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3

Target Organs

Central nervous system

Storage Class Code

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

WGK

WGK 3

Flash Point(F)

does not flash

Flash Point(C)

does not flash

Regulatory Information

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Activating the Intrinsic Pathway of Apoptosis Using BIM BH3 Peptides Delivered by Peptide Amphiphiles with Endosomal Release
Schnorenberg MR, et al.
Materials, 12(16), 2567-2567 (2019)
Effects of poly (ethylene glycol)(PEG) concentration on the permeability of PEG-grafted liposomes
Hashizaki K, et al.
Chemical & Pharmaceutical Bulletin, 53(1), 27-31 (2005)
Two cholesterol derivative-based PEGylated liposomes as drug delivery system, study on pharmacokinetics and drug delivery to retina
Geng S, et al.
Nanotechnology, 25(27), 275103-275103 (2014)
Preparation, characterization, cytotoxicity and pharmacokinetics of liposomes containing docetaxel
Immordino ML, et al.
Journal of Controlled Release : Official Journal of the Controlled Release Society, 91(3), 417-429 (2003)
Mathew R Schnorenberg et al.
Materials (Basel, Switzerland), 12(16) (2019-08-15)
Therapeutic manipulation of the BCL-2 family using BH3 mimetics is an emerging paradigm in cancer treatment and immune modulation. For example, peptides mimicking the BIM BH3 helix can directly target the full complement of anti- and pro-apoptotic BCL-2 proteins to

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